Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4F2 | P78329 | 1/20 | 0.34 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.32 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | GFER | P55789 | 1/20 | 0.32 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.31 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4444355 | 0.81 | CYP4F2 (0.38) | CYP4F2CYP4A11ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL27773085 | 0.80 | — | — | |
| SCHEMBL4444454 | 0.73 | MAPK1 (0.47) | ALDH1A1LMNASMN1; SMN2MAPTMAPK1 | |
| SCHEMBL1403072 | 0.68 | HSD11B1 (0.44) | ALDH1A1LMNASMN1; SMN2MEN1KMT2A | |
| SCHEMBL27794348 | 0.68 | CYP4F2 (0.32) | CYP4F2CYP4A11ALDH1A1SMN1; SMN2GAA | |
| SCHEMBL2440071 | 0.67 | SMN1; SMN2 (0.55) | CYP4F2CYP4A11ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL28785116 | 0.67 | CYP3A4 (0.34) | ALDH1A1LMNASMN1; SMN2MAPTMEN1 | |
| SCHEMBL4449523 | 0.65 | MAP2K4 (0.53) | ALDH1A1LMNASMN1; SMN2MAPTMAPK1 | |
| SCHEMBL4440046 | 0.65 | MAPK1 (0.50) | ALDH1A1LMNASMN1; SMN2MAPTMAPK1 | |
| SCHEMBL6301861 | 0.64 | CYP4F2 (0.59) | CYP4F2CYP4A11ALDH1A1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2124937-A1 | PYRAZOLE DERIVATIVES AS 11-BETA-HSD1 INHIBITORS | AstraZeneca AB (SE) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008099145-A1 | PYRAZOLE DERIVATIVES AS 11-BETA-HSD1 INHIBITORS | ASTRAZENECA AB (SE) | 2008-08-21 | — | — | WO | disclosed |