Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | GRK6 | P43250 | 1/20 | 0.46 |
| ▸ | MAP2K4 | P45985 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MYC | P01106 | 1/20 | 0.38 |
| ▸ | WDR5 | P61964 | 1/20 | 0.38 |
| ▸ | METAP2 | P50579 | 3/20 | 0.38 |
| ▸ | RAF1 | P04049 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27794357 | 0.77 | OPRD1 (0.36) | MAPK1GRK6ALDH1A1METAP2SMN1; SMN2 | |
| SCHEMBL4445486 | 0.73 | CYP4F2 (0.34) | MAPK1ALDH1A1SMN1; SMN2NPC1MAPT | |
| SCHEMBL8808192 | 0.66 | MAPK1 (0.54) | MAPK1MAP2K4KDM4EALDH1A1MYC | |
| SCHEMBL28042356 | 0.66 | SMN1; SMN2 (0.69) | MAPK1MAP2K4KDM4EALDH1A1RAF1 | |
| SCHEMBL8126956 | 0.65 | MAPK1 (0.72) | MAPK1MAP2K4KDM4EALDH1A1RAF1 | |
| SCHEMBL30079151 | 0.65 | CA1 (0.57) | MAPK1MAP2K4KDM4EALDH1A1MYC | |
| SCHEMBL1752774 | 0.65 | MAPK1 (0.64) | MAPK1MAP2K4KDM4EALDH1A1RAF1 | |
| SCHEMBL5173650 | 0.65 | PDE4D (0.55) | MAPK1MAP2K4KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL4440046 | 0.65 | MAPK1 (0.50) | MAPK1GRK6MAP2K4KDM4EALDH1A1 | |
| SCHEMBL4449523 | 0.65 | MAP2K4 (0.53) | MAPK1GRK6MAP2K4KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2124937-A1 | PYRAZOLE DERIVATIVES AS 11-BETA-HSD1 INHIBITORS | AstraZeneca AB (SE) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008099145-A1 | PYRAZOLE DERIVATIVES AS 11-BETA-HSD1 INHIBITORS | ASTRAZENECA AB (SE) | 2008-08-21 | — | — | WO | disclosed |