Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 9/20 | 0.48 |
| ▸ | GRIK2 | Q13002 | 6/20 | 0.48 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.48 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.48 |
| ▸ | SLC1A1 | P43005 | 4/20 | 0.46 |
| ▸ | GRIA4 | P48058 | 4/20 | 0.46 |
| ▸ | GRIK3 | Q13003 | 4/20 | 0.46 |
| ▸ | GRIK5 | Q16478 | 4/20 | 0.46 |
| ▸ | SLC1A3 | P43003 | 3/20 | 0.46 |
| ▸ | SLC1A2 | P43004 | 3/20 | 0.46 |
| ▸ | GRIA2 | P42262 | 3/20 | 0.46 |
| ▸ | GRIA1 | P42261 | 2/20 | 0.46 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.46 |
| ▸ | GRM8 | O00222 | 1/20 | 0.46 |
| ▸ | GRM6 | O15303 | 1/20 | 0.46 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.46 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.46 |
| ▸ | GSR | P00390 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | GRM5 | P41594 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10618897 | 0.79 | PTGS1 (0.55) | GRIK1GRIK2GRM1GRM2SLC1A1 | |
| SCHEMBL6832737 | 0.79 | PTGS1 (0.55) | GRIK1GRIK2GRM1GRM2SLC1A1 | |
| Asparagine SCHEMBL16372289 | 0.78 | ALOX15 (0.48) | GRIK1GRIK2GRM1GRM2SLC1A1 | |
| SCHEMBL7366965 | 0.77 | GRIK1 (0.50) | GRIK1GRIK2GRM1GRM2SLC1A1 | |
| SCHEMBL3145928 | 0.77 | GRIK1 (0.50) | GRIK1GRIK2GRM1GRM2SLC1A1 | |
| SCHEMBL564563 | 0.77 | GRIK1 (0.50) | GRIK1GRIK2GRM1GRM2SLC1A1 | |
| SCHEMBL3044802 | 0.77 | GRIK1 (0.50) | GRIK1GRIK2GRM1GRM2SLC1A1 | |
| SCHEMBL23829840 | 0.75 | GRIK1 (0.48) | GRIK1GRIK2GRM1GRM2SLC1A1 | |
| SCHEMBL6598328 | 0.75 | GRIK1 (0.48) | GRIK1GRIK2GRM1GRM2SLC1A1 | |
| SCHEMBL3286497 | 0.75 | GRIK1 (0.48) | GRIK1GRIK2GRM1GRM2SLC1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101506174-A | Caspase inhibitors based on pyridazinone scaffold | LG LIFE SCIENCES LTD (KR) | 2009-08-12 | — | — | CN | claimed |
| US-8481537-B2 | Caspase inhibitors based of pyridazinone scaffold | LG LIFE SCIENCES LTD. (KR) | 2013-07-09 | — | — | US | disclosed |
| CN-101506174-B | Caspase inhibitors based on pyridazinone scaffold | LG LIFE SCIENCES LTD | 2012-05-02 | — | — | CN | disclosed |
| CN-101506174-A | Caspase inhibitors based on pyridazinone scaffold | LG LIFE SCIENCES LTD (KR) | 2009-08-12 | — | — | CN | disclosed |
| EP-2046757-A1 | CASPASE INHIBITORS BASED ON PYRIDAZINONE SCAFFOLD | LG Life Sciences Ltd. (KR) | 2009-04-15 | — | — | EP | disclosed |
| CN-101217980-A | New combination of anti-MADCAM antibody and antifibrotic caspase inhibitor to treat liver fibrosis | PFIZER LTD (GB) | 2008-07-09 | — | — | CN | disclosed |
| WO-2008016239-A1 | CASPASE INHIBITORS BASED ON PYRIDAZINONE SCAFFOLD | LG LIFE SCIENCES LTD. (KR) | 2008-02-07 | — | — | WO | disclosed |
| EP-1480999-A2 | (SUBSTITUTED)ACYL DIPEPTIDYL INHIBITORS OF THE ICE/CED-3 FAMILY OF CYSTEINE PROTEASES | Idun Pharmaceuticals (US) | 2004-12-01 | — | — | EP | disclosed |
| WO-2003072528-A2 | (SUBSTITUTED)ACYL DIPEPTIDYL INHIBITORS OF THE ICE/CED-3 FAMILY OF CYSTEINE PROTEASES | IDUN PHARMACEUTICALS, INC. (US) | 2003-09-04 | — | — | WO | disclosed |