⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4679714 | 0.84 | — | — | |
| SCHEMBL12088001 | 0.83 | THRB (0.46) | — | |
| SCHEMBL1126985 | 0.83 | ALDH1A1 (0.36) | — | |
| SCHEMBL28140750 | 0.80 | THRB (0.44) | — | |
| SCHEMBL112379 | 0.80 | — | — | |
| Ammonia Solution, Strong SCHEMBL2039467 | 0.78 | THRB (0.55) | — | |
| Ammonia Solution, Strong SCHEMBL2805637 | 0.78 | THRB (0.55) | — | |
| Phosphine SCHEMBL5146648 | 0.78 | THRB (0.55) | — | |
| SCHEMBL202742 | 0.78 | — | — | |
| SCHEMBL4567264 | 0.78 | TSHR (0.52) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8815946-B2 | Inhibition of proliferation and fibrotic response of activated corneal stromal cells | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2014-08-26 | — | — | US | claimed |
| US-20090239947-A1 | Inhibition of proliferation and fibrotic response of activated corneal stromal cells | UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2009-09-24 | — | — | US | claimed |
| US-8815946-B2 | Inhibition of proliferation and fibrotic response of activated corneal stromal cells | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2014-08-26 | — | — | US | disclosed |
| US-20090239947-A1 | Inhibition of proliferation and fibrotic response of activated corneal stromal cells | UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2009-09-24 | — | — | US | disclosed |