Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | NAAA | Q02083 | 1/20 | 0.41 |
| ▸ | RAD52 | P43351 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 6/20 | 0.37 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1083216 | 0.90 | TSHR (0.67) | TSHRALDH1A1NAAARAD52NPSR1 | |
| SCHEMBL22607980 | 0.88 | TSHR (0.70) | TSHRALDH1A1NAAARAD52NPSR1 | |
| SCHEMBL6562247 | 0.88 | TSHR (0.70) | TSHRALDH1A1NAAARAD52NPSR1 | |
| SCHEMBL3018392 | 0.88 | TSHR (0.70) | TSHRALDH1A1NAAARAD52NPSR1 | |
| SCHEMBL521587 | 0.88 | TSHR (0.70) | TSHRALDH1A1NAAARAD52NPSR1 | |
| SCHEMBL22647718 | 0.88 | TSHR (0.70) | TSHRALDH1A1NAAARAD52NPSR1 | |
| SCHEMBL919347 | 0.88 | TSHR (0.70) | TSHRALDH1A1NAAARAD52NPSR1 | |
| SCHEMBL22647791 | 0.88 | TSHR (0.70) | TSHRALDH1A1NAAARAD52NPSR1 | |
| SCHEMBL22647724 | 0.88 | TSHR (0.70) | TSHRALDH1A1NAAARAD52NPSR1 | |
| SCHEMBL9345377 | 0.88 | TSHR (0.70) | TSHRALDH1A1NAAARAD52NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9221741-B2 | Ketocarboxylic acids, ketocarboxylic esters, methods of manufacture and uses thereof | SEGETIS, INC. (US) | 2015-12-29 | — | — | US | disclosed |
| US-9221741-B2 | Ketocarboxylic acids, ketocarboxylic esters, methods of manufacture and uses thereof | SEGETIS, INC. (US) | 2015-12-29 | — | — | US | disclosed |
| US-20130296601-A1 | KETOCARBOXYLIC ACIDS, KETOCARBOXYLIC ESTERS, METHODS OF MANUFACTURE AND USES THEREOF | GFBIOCHEMICALS LIMITED (MT) | 2013-11-07 | — | — | US | disclosed |
| US-20130296601-A1 | KETOCARBOXYLIC ACIDS, KETOCARBOXYLIC ESTERS, METHODS OF MANUFACTURE AND USES THEREOF | GFBIOCHEMICALS LIMITED (MT) | 2013-11-07 | — | — | US | disclosed |
| US-8507718-B2 | Ketocarboxylic acids, methods of manufacture and uses thereof | SEGETIS, INC. (US) | 2013-08-13 | — | — | US | disclosed |
| US-8507718-B2 | Ketocarboxylic acids, methods of manufacture and uses thereof | SEGETIS, INC. (US) | 2013-08-13 | — | — | US | disclosed |
| US-20120123147-A1 | KETOCARBOXYLIC ACIDS, METHODS OF MANUFACTURE AND USES THEREOF | SEGETIS, INC. (US) | 2012-05-17 | — | — | US | disclosed |
| US-20120123147-A1 | KETOCARBOXYLIC ACIDS, METHODS OF MANUFACTURE AND USES THEREOF | SEGETIS, INC. (US) | 2012-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120123147-A1 | KETOCARBOXYLIC ACIDS, METHODS OF MANUFACTURE AND USES THEREOF | PHYKPL, HACL2, MCCC2 | TSHR 4165/4885ALDH1A1 1223/4885NAAA 476/4885 |
| US-20130296601-A1 | KETOCARBOXYLIC ACIDS, KETOCARBOXYLIC ESTERS, METHODS OF MANUFACTURE AND USES THEREOF | PHYKPL, HACL2, MCCC2 | TSHR 3953/4885ALDH1A1 1119/4885NAAA 454/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.