Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | NSD2 | O96028 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | FABP4 | P15090 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | EDNRA | P25101 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4445447 | 0.88 | ALDH1A1 (0.46) | NSD2ALDH1A1MEN1KMT2AFABP4 | |
| SCHEMBL4452477 | 0.87 | MEN1 (0.48) | TP53HTTMEN1KMT2AFABP4 | |
| SCHEMBL4443167 | 0.84 | NSD2 (0.55) | NSD2ALDH1A1MEN1KMT2AFABP4 | |
| SCHEMBL4453211 | 0.84 | NSD2 (0.52) | TP53NSD2ALDH1A1FABP4SMN1; SMN2 | |
| SCHEMBL4444987 | 0.84 | NSD2 (0.66) | NSD2ALDH1A1MEN1KMT2AFABP4 | |
| SCHEMBL4449293 | 0.83 | MEN1 (0.45) | ALDH1A1MEN1KMT2AFABP4SMN1; SMN2 | |
| SCHEMBL6907327 | 0.83 | CASP6 (0.54) | TP53ALDH1A1HPGDHTTMEN1 | |
| SCHEMBL4453000 | 0.83 | NSD2 (0.53) | NSD2ALDH1A1FABP4SMN1; SMN2EDNRA | |
| SCHEMBL4454783 | 0.82 | NSD2 (0.69) | TP53NSD2ALDH1A1 | |
| SCHEMBL4444610 | 0.81 | FABP4 (0.51) | NSD2ALDH1A1FABP4EDNRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7547716-B2 | Sulfonamide derivatives | INSTITUTE OF MEDICINAL MOLECULAR DESIGN, INC. (JP) | 2009-06-16 | — | — | US | disclosed |
| EP-1402890-B1 | SULFONAMIDE DERIVATIVES | INST MED MOLECULAR DESIGN INC (JP) | 2008-01-09 | — | — | EP | disclosed |
| EP-1402890-A1 | SULFONAMIDE DERIVATIVES | Institute of Medicinal Molecular Design, Inc. (JP) | 2004-03-31 | — | — | EP | disclosed |