Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.47 |
| ▸ | CCR5 | P51681 | 1/20 | 0.41 |
| ▸ | CALCRL | Q16602 | 1/20 | 0.40 |
| ▸ | CCR3 | P51677 | 2/20 | 0.37 |
| ▸ | YEATS4 | O95619 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | PARG | Q86W56 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 3/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.36 |
| ▸ | PLD1 | Q13393 | 4/20 | 0.36 |
| ▸ | PLD2 | O14939 | 3/20 | 0.36 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | TNKS | O95271 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5000705 | 0.92 | OPRM1 (0.45) | OPRM1CCR5CALCRLCCR3YEATS4 | |
| SCHEMBL4435813 | 0.88 | OPRM1 (0.57) | OPRM1CALCRLYEATS4KCNH2DRD2 | |
| Hydrochloric Acid SCHEMBL4446657 | 0.87 | OPRM1 (0.56) | OPRM1CALCRLYEATS4KCNH2DRD2 | |
| SCHEMBL5000673 | 0.85 | OPRM1 (0.46) | OPRM1CCR5CALCRLCCR3YEATS4 | |
| SCHEMBL5000679 | 0.81 | OPRM1 (0.43) | OPRM1CCR5CALCRLCCR3YEATS4 | |
| SCHEMBL4991406 | 0.81 | OPRM1 (0.58) | OPRM1CALCRLYEATS4KCNH2DRD2 | |
| SCHEMBL4436712 | 0.80 | OPRM1 (0.48) | OPRM1YEATS4KCNH2DRD2CHRM1 | |
| SCHEMBL4436308 | 0.78 | OPRM1 (0.47) | OPRM1YEATS4KCNH2PARGDRD2 | |
| SCHEMBL4434744 | 0.77 | PLD2 (0.36) | CCR3YEATS4KCNH2CHRM1PLD1 | |
| SCHEMBL4444762 | 0.73 | OPRM1 (0.57) | OPRM1CALCRLYEATS4KCNH2DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121656-A1 | INHIBITORS OF SERINE PALMITOYLTRANSFERASE | Pfizer Products Inc. (US) | 2009-11-25 | — | — | EP | claimed |
| US-20080287479-A1 | INHIBITORS OF SERINE PALMITOYLTRANSFERASE | PFIZER INC | 2008-11-20 | — | — | US | claimed |
| WO-2008084300-A1 | INHIBITORS OF SERINE PALMITOYLTRANSFERASE | PFIZER PRODUCTS INC. (US) | 2008-07-17 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080287479-A1 | INHIBITORS OF SERINE PALMITOYLTRANSFERASE | SPTLC1, SPTLC2, CPT1A | OPRM1 4069/4885CCR5 1132/4885CALCRL 1266/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.