Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 3/20 | 0.46 |
| ▸ | HTR6 | P50406 | 4/20 | 0.45 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.44 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.44 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.44 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.44 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.44 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.44 |
| ▸ | NOD1 | Q9Y239 | 3/20 | 0.44 |
| ▸ | ALDH3A1 | P30838 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | PCSK9 | Q8NBP7 | 4/20 | 0.43 |
| ▸ | NOD2 | Q9HC29 | 2/20 | 0.42 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31304851 | 0.87 | HTR6 (0.44) | AGTR1HTR6NOD1CXCL8 | |
| SCHEMBL12271846 | 0.84 | AGTR1 (0.46) | AGTR1HTR6PSEN1PSEN2APH1B | |
| SCHEMBL25176785 | 0.82 | RAPGEF4 (0.50) | AGTR1HTR6PSEN1PSEN2APH1B | |
| SCHEMBL30958211 | 0.81 | MEN1 (0.45) | AGTR1HTR6PSEN1PSEN2APH1B | |
| SCHEMBL28178502 | 0.80 | GAA (0.51) | AGTR1HTR6PSEN1PSEN2APH1B | |
| SCHEMBL25540657 | 0.80 | AGTR1 (0.50) | AGTR1HTR6PSEN1PSEN2APH1B | |
| SCHEMBL30889670 | 0.78 | NOD1 (0.53) | AGTR1HTR6PSEN1PSEN2APH1B | |
| SCHEMBL30644289 | 0.77 | HTR6 (0.46) | AGTR1HTR6PSEN1PSEN2APH1B | |
| SCHEMBL597369 | 0.77 | HTR6 (0.46) | AGTR1HTR6PSEN1PSEN2APH1B | |
| SCHEMBL28145979 | 0.77 | NOD1 (0.57) | AGTR1NOD1ALDH3A1GAAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2069341-A1 | PYRROLO[2, 3-B]PYRIDIN-4-YL-BENZENESULFONAMIDE COMPOUNDS AS IKK2 INHIBITORS | Glaxo Group Limited (GB) | 2009-06-17 | — | — | EP | disclosed |
| WO-2008034860-A1 | PYRROLO[2, 3-B]PYRIDIN-4-YL-BENZENESULFONAMIDE COMPOUNDS AS IKK2 INHIBITORS | GLAXO GROUP LIMITED (GB) | 2008-03-27 | — | — | WO | disclosed |