⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27277009 | 0.82 | KDM4E (0.46) | — | |
| SCHEMBL11119 | 0.81 | — | — | |
| Formic Acid SCHEMBL1832326 | 0.79 | ALDH1A1 (0.40) | — | |
| SCHEMBL3318576 | 0.78 | ADH1B (0.44) | — | |
| SCHEMBL29060211 | 0.78 | — | — | |
| Fluoride SCHEMBL25246136 | 0.78 | KDM4E (0.42) | — | |
| Iodide SCHEMBL1835511 | 0.78 | KDM4E (0.42) | — | |
| SCHEMBL7790112 | 0.78 | KDM4E (0.42) | — | |
| Hydrogen Sulfide SCHEMBL3631297 | 0.78 | KDM4E (0.42) | — | |
| SCHEMBL3631301 | 0.78 | KDM4E (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140286943-A1 | CYCLOPROPYL MODULATORS OF P2Y12 RECEPTOR | AUSPEX PHARMACEUTICALS INC (US) | 2014-09-25 | — | — | US | disclosed |
| US-20140179829-A1 | WATER BASED EPOXY RESIN PRIMER | SIKA TECHNOLOGY AG (CH) | 2014-06-26 | — | — | US | disclosed |
| CN-1914182-B | Quinazoline derivatives | ASTRAZENECA AB | 2011-09-07 | — | — | CN | disclosed |
| US-7632840-B2 | Quinazoline compounds for the treatment of hyperproliferative disorders | ASTRAZENECA AB (SE) | 2009-12-15 | — | — | US | disclosed |
| WO-2009049098-A2 | MATERIALS AND METHODS FOR REGULATING THE ACTIVITY OF PHOSPHATASES | INDIANA UNIVERSITY RESEARCH & TECHNOLOGY CORPORATION (US) | 2009-04-16 | — | — | WO | disclosed |
| EP-1713781-B1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2008-11-05 | — | — | EP | disclosed |
| US-20070293490-A1 | Quinazoline Derivatives | ASTRAZENECA AB (SE) | 2007-12-20 | — | — | US | disclosed |
| CN-1914182-A | Quinazoline derivatives | ASTRAZENECA AB (SE) | 2007-02-14 | — | — | CN | disclosed |
| EP-1713781-A1 | QUINAZOLINE DERIVATIVES | AstraZeneca AB (SE) | 2006-10-25 | — | — | EP | disclosed |
| WO-2005075439-A1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2005-08-18 | — | — | WO | disclosed |