Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 2/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.36 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL44007 | 0.92 | ALDH1A1 (0.41) | ROCK1ROCK2TP53LMNAPIK3CA | |
| SCHEMBL44171 | 0.91 | ROCK1 (0.41) | ROCK1ROCK2PIK3CAPIK3CGEGLN1 | |
| SCHEMBL44411 | 0.88 | LMNA (0.44) | ROCK1ROCK2LMNAHPGDALDH1A1 | |
| SCHEMBL44731 | 0.88 | ROCK1 (0.39) | ROCK1ROCK2PIK3CAPIK3CGEGLN1 | |
| SCHEMBL13844884 | 0.86 | WDR5 (0.41) | ROCK1ROCK2TP53LMNAGAA | |
| SCHEMBL12951391 | 0.86 | WDR5 (0.41) | ROCK1ROCK2TP53LMNAHPGD | |
| SCHEMBL44338 | 0.86 | WDR5 (0.41) | ROCK1ROCK2TP53LMNAKDM4E | |
| SCHEMBL12951392 | 0.85 | WDR5 (0.41) | ROCK1ROCK2TP53CYP2C9WDR5 | |
| SCHEMBL44165 | 0.85 | LMNA (0.48) | ROCK1ROCK2LMNAHPGDCYP2C9 | |
| SCHEMBL43999 | 0.84 | EGLN2 (0.45) | ROCK1ROCK2EGLN1CYP2C9WDR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011137587-A1 | CYTOKINE INHIBITORS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-11-10 | — | — | WO | claimed |
| WO-2011137587-A1 | CYTOKINE INHIBITORS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-11-10 | — | — | WO | disclosed |