Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6744989 | 0.81 | NLRP3 (0.59) | NLRP3ALDH1A1KMT2AMEN1GAA | |
| SCHEMBL18301079 | 0.75 | NLRP3 (0.52) | NLRP3ALDH1A1GAAKDM4ESMN1; SMN2 | |
| SCHEMBL16792371 | 0.73 | NLRP3 (0.48) | NLRP3ALDH1A1KMT2ALMNAMEN1 | |
| SCHEMBL20201867 | 0.71 | CYP4F2 (0.56) | NLRP3ALDH1A1KMT2ALMNAGAA | |
| SCHEMBL20562586 | 0.70 | MTNR1A (0.49) | ALDH1A1KMT2AMEN1SMN1; SMN2NPC1 | |
| SCHEMBL15012550 | 0.70 | NLRP3 (0.50) | NLRP3ALDH1A1GAAMAPTKDM4E | |
| SCHEMBL4832334 | 0.69 | SMN1; SMN2 (0.43) | NLRP3ALDH1A1KMT2ALMNAMEN1 | |
| SCHEMBL2058956 | 0.69 | NLRP3 (0.57) | NLRP3ALDH1A1KMT2AMEN1GAA | |
| SCHEMBL18301081 | 0.69 | ALDH1A1 (0.45) | NLRP3ALDH1A1GAAL3MBTL1KDM4E | |
| SCHEMBL257483 | 0.68 | USP2 (0.58) | NLRP3ALDH1A1KMT2ALMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121598-A2 | COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF CANNABINOID RECEPTOR 1 ACTIVITY | IRM LLC (BM) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008076754-A2 | COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF CANNABINOID RECEPTOR 1 ACTIVITY | IRM LLC (BM) | 2008-06-26 | — | — | WO | disclosed |