Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 5/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | PPARA | Q07869 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | CASP7 | P55210 | 1/20 | 0.43 |
| ▸ | CASP9 | P55211 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18301079 | 0.89 | NLRP3 (0.52) | NLRP3GAANPSR1SMN1; SMN2KDM4E | |
| SCHEMBL16792371 | 0.84 | NLRP3 (0.48) | NLRP3GAANPSR1SMN1; SMN2KDM4E | |
| SCHEMBL4832334 | 0.82 | SMN1; SMN2 (0.43) | NLRP3SMN1; SMN2KDM4EALDH1A1KMT2A | |
| SCHEMBL2058956 | 0.82 | NLRP3 (0.57) | NLRP3GAANPSR1SMN1; SMN2KDM4E | |
| SCHEMBL18301081 | 0.82 | ALDH1A1 (0.45) | NLRP3GAANPSR1SMN1; SMN2KDM4E | |
| SCHEMBL257483 | 0.81 | USP2 (0.58) | NLRP3NPSR1SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL4447221 | 0.81 | NLRP3 (0.48) | NLRP3GAASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL24756033 | 0.81 | NLRP3 (0.43) | NLRP3GAANPSR1SMN1; SMN2KDM4E | |
| SCHEMBL14252839 | 0.81 | CA12 (0.55) | NLRP3GAANPSR1SMN1; SMN2KDM4E | |
| SCHEMBL18301092 | 0.80 | NLRP3 (0.52) | NLRP3GAANPSR1SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200384134-A1 | IMAGING METHOD OF AMPA RECEPTORS IN BRAIN OF PRIMATE ORGANISM, PROGRAM, DIAGNOSTIC AGENT, COMPANION DIAGNOSTIC AGENT, DRUG, SCREENING METHOD, INPUT TERMINAL, SERVER AND SYSTEM | PUBLIC UNIVERSITY CORPORATION YOKOHAMA CITY UNIVERSITY (JP) | 2020-12-10 | — | — | US | disclosed |
| US-20200384134-A1 | IMAGING METHOD OF AMPA RECEPTORS IN BRAIN OF PRIMATE ORGANISM, PROGRAM, DIAGNOSTIC AGENT, COMPANION DIAGNOSTIC AGENT, DRUG, SCREENING METHOD, INPUT TERMINAL, SERVER AND SYSTEM | PUBLIC UNIVERSITY CORPORATION YOKOHAMA CITY UNIVERSITY (JP) | 2020-12-10 | — | — | US | disclosed |
| EP-3321252-B1 | NOVEL COMPOUND THAT SPECIFICALLY BINDS TO AMPA RECEPTOR | PUBLIC UNIV CORP YOKOHAMA CITY UNIV (JP) | 2020-10-21 | — | — | EP | disclosed |
| CN-107922328-B | Novel compounds that specifically bind to AMPA receptors | 公立大学法人横滨市立大学 | 2020-05-19 | — | — | CN | disclosed |
| EP-3569255-A1 | IMAGING METHOD OF AMPA RECEPTORS IN BRAIN OF PRIMATE ORGANISM, PROGRAM, DIAGNOSTIC AGENT, COMPANION DIAGNOSTIC AGENT, DRUG, SCREENING METHOD, INPUT TERMINAL, SERVER AND SYSTEM | Public University Corporation Yokohama City University (JP) | 2019-11-20 | — | — | EP | disclosed |
| US-10335503-B2 | Compound that specifically binds to AMPA receptor | PUBLIC UNIVERSITY CORPORATION YOKOHAMA CITY UNIVERSITY (JP) | 2019-07-02 | — | — | US | disclosed |
| US-10335503-B2 | Compound that specifically binds to AMPA receptor | PUBLIC UNIVERSITY CORPORATION YOKOHAMA CITY UNIVERSITY (JP) | 2019-07-02 | — | — | US | disclosed |
| US-20180200391-A1 | NOVEL COMPOUND THAT SPECIFICALLY BINDS TO AMPA RECEPTOR | PUBLIC UNIVERSITY CORPORATION YOKOHAMA CITY UNIVERSITY (JP) | 2018-07-19 | — | — | US | disclosed |
| US-20180200391-A1 | NOVEL COMPOUND THAT SPECIFICALLY BINDS TO AMPA RECEPTOR | PUBLIC UNIVERSITY CORPORATION YOKOHAMA CITY UNIVERSITY (JP) | 2018-07-19 | — | — | US | disclosed |
| US-20180200391-A1 | NOVEL COMPOUND THAT SPECIFICALLY BINDS TO AMPA RECEPTOR | PUBLIC UNIVERSITY CORPORATION YOKOHAMA CITY UNIVERSITY (JP) | 2018-07-19 | — | — | US | disclosed |
| EP-3321252-A1 | NOVEL COMPOUND THAT SPECIFICALLY BINDS TO AMPA RECEPTOR | Public University Corporation Yokohama City University (JP) | 2018-05-16 | — | — | EP | disclosed |
| WO-2017006931-A1 | NOVEL COMPOUND THAT SPECIFICALLY BINDS TO AMPA RECEPTOR | 公立大学法人横浜市立大学 | 2017-01-12 | — | — | WO | disclosed |
| US-6696494-B2 | HUMAN IMMUNODEFICIENCY VIRUS | ENANTA PHARMACEUTICALS, INC. | 2004-02-24 | — | — | US | disclosed |
| US-20030207934-A1 | Alpha-hydroxyarylbutanamine inhibitors of aspartyl protease | ENANTA PHARMACEUTICALS, INC. | 2003-11-06 | — | — | US | disclosed |
| WO-2003034989-A2 | α-HYDROXYARYLBUTANAMINE INHIBITORS OF ASPARTYL PROTEASE | ENANTA PHARMACEUTICALS, INC. (US) | 2003-05-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180200391-A1 | NOVEL COMPOUND THAT SPECIFICALLY BINDS TO AMPA RECEPTOR | GRM3, GRM1, GRIN3A | NLRP3 2173/4885GAA 2607/4885NPSR1 93/4885 |
| US-20030207934-A1 | Alpha-hydroxyarylbutanamine inhibitors of aspartyl protease | DNPEP, ASPH, CTSC | NLRP3 3475/4885GAA 22/4885NPSR1 3625/4885 |
| US-10335503-B2 | Compound that specifically binds to AMPA receptor | GRM3, GRIN3A, GRM1 | NLRP3 2012/4885GAA 2520/4885NPSR1 91/4885 |
| US-20200384134-A1 | IMAGING METHOD OF AMPA RECEPTORS IN BRAIN OF PRIMATE ORGANISM, PROGRAM, DIAGNOSTIC AGENT, COMPANION DIAGNOSTIC AGENT, DRUG, SCREENING METHOD, INPUT TERMINAL, SERVER AND SYSTEM | SLC1A2, SLC1A1, SLC1A3 | NLRP3 2649/4885GAA 3722/4885NPSR1 295/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.