Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.42 |
| ▸ | ACR | P10323 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | ELANE | P08246 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7064531 | 0.88 | LMNA (0.70) | LMNAALDH1A1L3MBTL1GAAKMT2A | |
| SCHEMBL146180 | 0.83 | LMNA (0.63) | LMNAALDH1A1L3MBTL1GAAKMT2A | |
| SCHEMBL6618980 | 0.82 | CES2 (0.52) | LMNAALDH1A1GAACYP1A2CYP2C9 | |
| SCHEMBL27568757 | 0.82 | LMNA (0.61) | LMNAALDH1A1L3MBTL1GAAKMT2A | |
| SCHEMBL24158 | 0.82 | ELANE (0.48) | LMNAALDH1A1GAAKMT2AELANE | |
| SCHEMBL7553867 | 0.82 | LMNA (0.61) | LMNAALDH1A1L3MBTL1GAAKMT2A | |
| SCHEMBL280615 | 0.81 | LMNA (1.00) | LMNAALDH1A1GAAKMT2ACYP1A2 | |
| SCHEMBL27768540 | 0.81 | LMNA (0.61) | LMNAALDH1A1L3MBTL1GAAKMT2A | |
| SCHEMBL23174644 | 0.80 | ELANE (0.44) | LMNAALDH1A1GAAKMT2AELANE | |
| SCHEMBL8467442 | 0.80 | LMNA (0.59) | LMNAALDH1A1L3MBTL1GAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8815946-B2 | Inhibition of proliferation and fibrotic response of activated corneal stromal cells | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2014-08-26 | — | — | US | claimed |
| US-20090239947-A1 | Inhibition of proliferation and fibrotic response of activated corneal stromal cells | UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2009-09-24 | — | — | US | claimed |
| US-4481368-A | Process for preparing α-keto-carboxylic acids from acyl halides | ETHYL CORPORATION (US) | 1984-11-06 | — | — | US | claimed |
| US-4481369-A | VIA TRICARBONYL(TRIPHENYLPOSPHINE) COBALTATE | ETHYL CORPORATION (US) | 1984-11-06 | — | — | US | claimed |
| US-8815946-B2 | Inhibition of proliferation and fibrotic response of activated corneal stromal cells | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2014-08-26 | — | — | US | disclosed |
| EP-2574667-A1 | Enzyme variants | Technische Universität Graz (AT) | 2013-04-03 | — | — | EP | disclosed |
| US-20090239947-A1 | Inhibition of proliferation and fibrotic response of activated corneal stromal cells | UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2009-09-24 | — | — | US | disclosed |
| EP-0407588-B1 | PROCESS FOR PRODUCING 2-OXO-3-AROMATIC CARBOXYLIC ACID DERIVATIVES | SAGAMI CHEM RES (JP) | 1993-12-08 | — | — | EP | disclosed |
| EP-0206460-B1 | L-PHENYLALANINE DEHYDROGENASE AND USE THEREOF | SAGAMI CHEMICAL RESEARCH CENTER (JP) | 1993-08-11 | — | — | EP | disclosed |
| EP-0513872-A1 | L-phenylalanine dehydrogenase and use thereof | SAGAMI CHEMICAL RESEARCH CENTER (JP) | 1992-11-19 | — | — | EP | disclosed |
| US-5028738-A | Process for producing 2-oxo-3-aromatic carboxylic acid derivatives | SAGAMI CHEMICAL RESEARCH CENTER (JP) | 1991-07-02 | — | — | US | disclosed |
| EP-0407588-A1 | PROCESS FOR PRODUCING 2-OXO-3-AROMATIC CARBOXYLIC ACID DERIVATIVES | SAGAMI CHEMICAL RESEARCH CENTER (JP) | 1991-01-16 | — | — | EP | disclosed |
| US-4849345-A | L-phenylalanine dehydrogenase and use thereof | SAGAMI CHEMICAL RESEARCH CENTER (JP) | 1989-07-18 | — | — | US | disclosed |
| EP-0206460-A2 | L-phenylalanine dehydrogenase and use thereof | SAGAMI CHEMICAL RESEARCH CENTER (JP) | 1986-12-30 | — | — | EP | disclosed |
| US-4481369-A | VIA TRICARBONYL(TRIPHENYLPOSPHINE) COBALTATE | ETHYL CORPORATION (US) | 1984-11-06 | — | — | US | disclosed |
| US-4481368-A | Process for preparing α-keto-carboxylic acids from acyl halides | ETHYL CORPORATION (US) | 1984-11-06 | — | — | US | disclosed |
| US-4447644-A | Method for preparation of arylpyruvic acid | DYNAMIT NOBEL AG (DE) | 1984-05-08 | — | — | US | disclosed |
| US-4152352-A | PRODUCTION OF ARYLPYRUVIC ACIDS | RHONE-POULENC INDUSTRIES (FR) | 1979-05-01 | — | — | US | disclosed |