Known targets — ChEMBL curated mechanism
ABL1BMXBRAFBTKCHRNA4CHRNB2CSNK1EEGFRERBB2F10FLT1FLT3FLT4IGF1RINSRITKJAK3KDRKITOPRM1PARP1PARP2PDGFRBPIK3CDRAF1RETSLC18A2TECTXKdacAdacBdacCftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | CA2 | P00918 | 5/20 | 0.44 |
| ▸ | CA1 | P00915 | 4/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | AR | P10275 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL57630 | 0.87 | LMNA (0.62) | LMNAMAPTCYP1A2CYP2C9KMT2A | |
| SCHEMBL10499588 | 0.86 | ALDH1A1 (0.52) | MAPTCYP1A2CYP2C9KMT2AALDH1A1 | |
| SCHEMBL1455487 | 0.84 | LMNA (0.60) | LMNAMAPTCYP1A2CYP2C9KMT2A | |
| SCHEMBL5538472 | 0.84 | L3MBTL1 (0.54) | LMNAMAPTCYP1A2CYP2C9KMT2A | |
| SCHEMBL18281078 | 0.83 | LMNA (0.68) | LMNAMAPTCYP1A2CYP2C9KMT2A | |
| SCHEMBL717926 | 0.83 | LMNA (0.68) | LMNAMAPTCYP1A2CYP2C9KMT2A | |
| Hydrochloric Acid SCHEMBL715023 | 0.83 | L3MBTL1 (0.53) | LMNAMAPTCYP1A2CYP2C9KMT2A | |
| SCHEMBL2536 | 0.82 | LMNA (0.57) | LMNAMAPTCYP1A2CYP2C9KMT2A | |
| SCHEMBL1177430 | 0.81 | LMNA (0.62) | LMNAMAPTCYP1A2CYP2C9KMT2A | |
| SCHEMBL26287992 | 0.81 | L3MBTL1 (0.51) | LMNAMAPTCYP1A2CYP2C9KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090005321-A1 | Phenylazetidinone Derivatives | MICROBIA, INC. (US) | 2009-01-01 | — | — | US | disclosed |
| EP-1851197-A2 | PHENYLAZETIDINONE DERIVATIVES | Microbia, Inc. (US) | 2007-11-07 | — | — | EP | disclosed |
| WO-2006086562-A2 | PHENYLAZETIDINONE DERIVATIVES | MICROBIA, INC. (US) | 2006-08-17 | — | — | WO | disclosed |
| EP-0498268-A2 | 5-Oxo-L-proline derivatives and pharmaceutical use thereof | POLI INDUSTRIA CHIMICA S.p.A. (IT) | 1992-08-12 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090005321-A1 | Phenylazetidinone Derivatives | TYR, AAAS, FANCD2 | LMNA 1163/4885MAPT 1936/4885CYP1A2 81/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.