SCHEMBL444839

SCHEMBL444839

c1ccc(-c2cc3c(-c4ccccc4)n(-c4ccccc4)c(-c4ccccc4)c3cc2-c2ccccc2)cc1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
IL1R1 P14778 1/20 0.41
KMT2A Q03164 4/20 0.40
ALDH1A1 P00352 3/20 0.40
KDM4E B2RXH2 3/20 0.40
MEN1 O00255 3/20 0.40
L3MBTL1 Q9Y468 2/20 0.40
MAPT P10636 1/20 0.40
HTT P42858 1/20 0.40
ATM Q13315 1/20 0.40
LMNA P02545 2/20 0.40
SMN1; SMN2 Q16637 2/20 0.40
HPGD P15428 2/20 0.40
RECQL P46063 2/20 0.39
POLB P06746 1/20 0.39
BACE1 P56817 1/20 0.38
MAPK1 P28482 1/20 0.38
BCHE P06276 1/20 0.37
ACHE P22303 1/20 0.37
GAA P10253 2/20 0.35
AVPR1A P37288 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL442622 0.86 BRD9 (0.41) IL1R1KMT2AALDH1A1KDM4EMEN1
SCHEMBL443170 0.82 KDM4E (0.52) IL1R1KMT2AALDH1A1KDM4EMEN1
SCHEMBL444851 0.82 IL1R1 (0.44) IL1R1KMT2AALDH1A1KDM4EMEN1
SCHEMBL7919034 0.75 LMNA (0.50) KMT2AALDH1A1KDM4EMEN1L3MBTL1
SCHEMBL31438454 0.74 BACE1 (0.55) KMT2AALDH1A1KDM4EMEN1MAPT
SCHEMBL311836 0.74 BACE1 (0.55) KMT2AALDH1A1KDM4EMEN1MAPT
SCHEMBL17911727 0.73 ALDH1A1 (0.44) IL1R1KMT2AALDH1A1KDM4EMEN1
SCHEMBL711566 0.72 IL1R1 (0.42) IL1R1KMT2AALDH1A1KDM4EMEN1
SCHEMBL10205955 0.72 ALDH1A1 (0.43) KMT2AALDH1A1KDM4EMEN1MAPT
SCHEMBL15926661 0.72 L3MBTL1 (0.62) IL1R1KMT2AALDH1A1KDM4EMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8809543-B2 Electrophotographic photoreceptor, electrophotographic image forming method, electrophotographic image forming apparatus, and process cartridge for electrophotographic image forming apparatus RICOH COMPANY, LTD. (JP) 2014-08-19 US disclosed
US-8809543-B2 Electrophotographic photoreceptor, electrophotographic image forming method, electrophotographic image forming apparatus, and process cartridge for electrophotographic image forming apparatus RICOH COMPANY, LTD. (JP) 2014-08-19 US disclosed
US-20120064443-A1 ELECTROPHOTOGRAPHIC PHOTORECEPTOR, ELECTROPHOTOGRAPHIC IMAGE FORMING METHOD, ELECTROPHOTOGRAPHIC IMAGE FORMING APPARATUS, AND PROCESS CARTRIDGE FOR ELECTROPHOTOGRAPHIC IMAGE FORMING APPARATUS RICOH COMPANY, LTD. (JP) 2012-03-15 US disclosed
US-20120064443-A1 ELECTROPHOTOGRAPHIC PHOTORECEPTOR, ELECTROPHOTOGRAPHIC IMAGE FORMING METHOD, ELECTROPHOTOGRAPHIC IMAGE FORMING APPARATUS, AND PROCESS CARTRIDGE FOR ELECTROPHOTOGRAPHIC IMAGE FORMING APPARATUS RICOH COMPANY, LTD. (JP) 2012-03-15 US disclosed