Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 1/20 | 0.40 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 3/20 | 0.38 |
| ▸ | PPARA | Q07869 | 3/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | PPARD | Q03181 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TYMP | P19971 | 1/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | ADK | P55263 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30831131 | 0.90 | DNMT1 (0.39) | DHFRDNMT1CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL12903863 | 0.81 | DHFR (0.46) | DHFRDNMT1ALDH1A1MAPTRAB9A | |
| SCHEMBL7069207 | 0.77 | DNMT1 (0.42) | DHFRDNMT1ALDH1A1MAPTRAB9A | |
| SCHEMBL18922438 | 0.74 | GSK3B (0.36) | DHFRDNMT1PPARGPPARACYP2C9 | |
| SCHEMBL10434031 | 0.74 | ALDH1A1 (0.44) | DHFRDNMT1CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL10434030 | 0.73 | DHFR (0.40) | DHFRDNMT1ALDH1A1MAPTRAB9A | |
| SCHEMBL1095987 | 0.72 | ALDH1A1 (0.43) | DHFRPPARGPPARACYP2C9CYP2C19 | |
| SCHEMBL30122801 | 0.72 | DNMT1 (0.47) | DHFRDNMT1ALDH1A1MAPTRAB9A | |
| SCHEMBL1933357 | 0.72 | TLR8 (0.38) | DHFRDNMT1ALDH1A1MAPTRAB9A | |
| SCHEMBL9756475 | 0.71 | DNMT1 (0.46) | DHFRDNMT1ALDH1A1MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2012779-A2 | PROCESS FOR THE PREPARATION OF INDAZOLYL UREAS THAT INHIBIT VANILLOID SUBTYPE 1 (VR1) RECEPTORS | Abbott Laboratories (US) | 2009-01-14 | — | — | EP | claimed |
| WO-2007121339-A2 | PROCESS FOR THE PREPARATION OF INDAZOLYL UREAS THAT INHIBIT VANILLOID SUBTYPE 1 (VR1) RECEPTORS | ABBOTT LABORATORIES (US) | 2007-10-25 | — | — | WO | claimed |