Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 4/20 | 0.68 |
| ▸ | GABRP | O00591 | 2/20 | 0.60 |
| ▸ | GABRD | O14764 | 2/20 | 0.60 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.60 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.60 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.60 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.60 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.60 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.60 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.60 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.60 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.60 |
| ▸ | GABRE | P78334 | 2/20 | 0.60 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.60 |
| ▸ | GABRG1 | Q8N1C3 | 2/20 | 0.60 |
| ▸ | GABRG3 | Q99928 | 2/20 | 0.60 |
| ▸ | GABRQ | Q9UN88 | 2/20 | 0.60 |
| ▸ | TNKS | O95271 | 1/20 | 0.60 |
| ▸ | PARP1 | P09874 | 1/20 | 0.60 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4659168 | 0.88 | MAOB (0.78) | MAOBALOX5CA1CA2CA9 | |
| SCHEMBL5768216 | 0.84 | MAOB (0.72) | MAOBGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL731363 | 0.84 | MAOB (0.71) | MAOBGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL31105656 | 0.84 | MAOB (0.71) | MAOBGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL28088015 | 0.81 | MAOB (0.65) | MAOBGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL29811226 | 0.81 | MAOB (0.65) | MAOBGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL7125605 | 0.81 | MAOB (0.68) | MAOBALOX5CA1CA2CA9 | |
| SCHEMBL5032926 | 0.81 | ESR1 (0.70) | MAOBTNKSALOX5CA1CA2 | |
| SCHEMBL791728 | 0.81 | MAOB (0.68) | MAOBALOX5CA1CA2CA9 | |
| SCHEMBL1772762 | 0.81 | MAOB (1.00) | MAOBGABRPGABRDGABRA1GABRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110386909-B | Method for synthesizing benzofuran derivative through copper-free ligand-free palladium catalyst | 中国科学院青岛生物能源与过程研究所 | 2023-07-07 | — | — | CN | disclosed |
| US-11033889-B2 | Palladium acyclic diaminocarbene complexes as precatalysts for Hiyama coupling and the tandem one-pot fluoride free Hiyama coupling/cyclization for the synthesis of biologically relevant | INDIAN INSTITUTE OF TECHNOLOGY BOMBAY (IN) | 2021-06-15 | — | — | US | disclosed |
| US-11033889-B2 | Palladium acyclic diaminocarbene complexes as precatalysts for Hiyama coupling and the tandem one-pot fluoride free Hiyama coupling/cyclization for the synthesis of biologically relevant | INDIAN INSTITUTE OF TECHNOLOGY BOMBAY (IN) | 2021-06-15 | — | — | US | disclosed |
| US-20200122132-A1 | PALLADIUM ACYCLIC DIAMINOCARBENE COMPLEXES AS PRECATALYSTS FOR HIYAMA COUPLING AND THE TANDEM ONE-POT FLUORIDE FREE HIYAMA COUPLING/CYCLIZATION FOR THE SYNTHESIS OF BIOLOGICALLY RELEVANT | INDIAN INSTITUTE OF TECHNOLOGY BOMBAY (IN) | 2020-04-23 | — | — | US | disclosed |
| US-20200122132-A1 | PALLADIUM ACYCLIC DIAMINOCARBENE COMPLEXES AS PRECATALYSTS FOR HIYAMA COUPLING AND THE TANDEM ONE-POT FLUORIDE FREE HIYAMA COUPLING/CYCLIZATION FOR THE SYNTHESIS OF BIOLOGICALLY RELEVANT | INDIAN INSTITUTE OF TECHNOLOGY BOMBAY (IN) | 2020-04-23 | — | — | US | disclosed |
| CN-110386909-A | A method of benzofuran derivatives are synthesized by no copper catalysis of ligand-free palladium agent | 中国科学院青岛生物能源与过程研究所 | 2019-10-29 | — | — | CN | disclosed |
| CN-108440515-A | Substituted benzofuranyl and benzoxazole based compound and application thereof | 卡尔约药物治疗公司 | 2018-08-24 | — | — | CN | disclosed |
| CN-108137497-A | Bicyclic derivatives, process for their preparation and pharmaceutical compositions containing them | 法国施维雅药厂 | 2018-06-08 | — | — | CN | disclosed |
| CN-108137563-A | (S, E) -3- (6-aminopyridin-3-yl) -N- ((5- (4- (3-fluoro-3-methylpyrrolidine-l-carbonyl) phenyl) -7- (4-fluorophenyl) benzofuran-2-yl) methyl) acrylamide for the treatment of cancer | 卡尔约药物治疗公司 | 2018-06-08 | — | — | CN | disclosed |
| CN-105492437-B | Substituted benzofuranyl and benzoxazolyl compounds and uses thereof | 卡尔约药物治疗公司 | 2018-05-11 | — | — | CN | disclosed |
| EP-1373259-A1 | PYRIDAZINONE ALDOSE REDUCTASE INHIBITORS | Pfizer Products Inc. (US) | 2004-01-02 | — | — | EP | disclosed |
| US-20030162784-A1 | Pyridazinone aldose reductase inhibitors | MYLARI BANAVARA L (US) | 2003-08-28 | — | — | US | disclosed |
| US-6579879-B2 | Pyridazinone aldose reductase inhibitors | PFIZER INC | 2003-06-17 | — | — | US | disclosed |
| WO-2002087584-A1 | COMBINATIONS OF ALDOSE REDUCTASE INHIBITORS AND CYCLOOXYGENASE-2 INHIBITORS | PFIZER PRODUCTS INC. (US) | 2002-11-07 | — | — | WO | disclosed |
| WO-2002079198-A1 | PYRIDAZINONE ALDOSE REDUCTASE INHIBITORS | PFIZER PRODUCTS INC. (US) | 2002-10-10 | — | — | WO | disclosed |
| US-20020143017-A1 | Pyridazinone aldose reductase inhibitors | MYLARI BANAVARA L (US) | 2002-10-03 | — | — | US | disclosed |
| US-4117128-A | SULFONYL BENZOFURANS AND BENZOTHIOPHENES HAVING CORONARY VASODILATOR ACTIVITY | SMITHKLINE CORPORATION (US) | 1978-09-26 | — | — | US | disclosed |
| US-4024273-A | Coronary vasodilator and anti-anginal compositions comprising substituted benzofurans and benzothiophenes and methods of producing coronary vasodilation and anti-anginal activity | SMITHKLINE CORPORATION (US) | 1977-05-17 | — | — | US | disclosed |
| US-3983245-A | CORONARY VASODILATORS | SMITHKLINE CORPORATION (US) | 1976-09-28 | — | — | US | disclosed |
| US-3947470-A | CORONARY VASODILATORS, TREATMENT OF ANGINA PECTORIS | SMITHKLINE CORPORATION (US) | 1976-03-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200122132-A1 | PALLADIUM ACYCLIC DIAMINOCARBENE COMPLEXES AS PRECATALYSTS FOR HIYAMA COUPLING AND THE TANDEM ONE-POT FLUORIDE FREE HIYAMA COUPLING/CYCLIZATION FOR THE SYNTHESIS OF BIOLOGICALLY RELEVANT | PAICS, AOC1, FLI1 | MAOB 351/4885GABRP 2755/4885GABRD 3571/4885 |
| US-20030162784-A1 | Pyridazinone aldose reductase inhibitors | SLC5A1, ALDOA, AKR1B1 | MAOB 132/4885GABRP 905/4885GABRD 1591/4885 |
| US-20020143017-A1 | Pyridazinone aldose reductase inhibitors | SLC5A1, AKR1B1, AKR1D1 | MAOB 176/4885GABRP 1442/4885GABRD 1466/4885 |
| US-11033889-B2 | Palladium acyclic diaminocarbene complexes as precatalysts for Hiyama coupling and the tandem one-pot fluoride free Hiyama coupling/cyclization for the synthesis of biologically relevant | PAICS, AOC1, FLI1 | MAOB 351/4885GABRP 2755/4885GABRD 3571/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.