Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | TACR2 | P21452 | 8/20 | 0.45 |
| ▸ | TACR3 | P29371 | 8/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.45 |
| ▸ | TP53 | P04637 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6626579 | 0.85 | ALDH1A1 (0.56) | LMNATACR2TACR3OPRM1TP53 | |
| SCHEMBL6625208 | 0.82 | LMNA (0.53) | LMNATACR2TACR3OPRM1TP53 | |
| SCHEMBL4449047 | 0.82 | LMNA (0.69) | LMNATACR3TP53MAPTALDH1A1 | |
| SCHEMBL5046700 | 0.80 | LMNA (0.61) | LMNATACR3TP53ALDH1A1HPGD | |
| SCHEMBL1580933 | 0.80 | TACR3 (0.62) | TACR2TACR3OPRM1 | |
| SCHEMBL8190048 | 0.80 | TACR3 (0.62) | TACR2TACR3OPRM1 | |
| SCHEMBL7003424 | 0.80 | LMNA (0.50) | LMNATACR2TACR3OPRM1TP53 | |
| SCHEMBL4665926 | 0.79 | LMNA (0.48) | LMNATACR2TACR3OPRM1TP53 | |
| SCHEMBL4667076 | 0.79 | LMNA (0.48) | LMNATACR2TACR3OPRM1TP53 | |
| SCHEMBL6629503 | 0.79 | LMNA (0.52) | LMNATACR2TACR3OPRM1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1928835-A1 | ALKYL SULFOXIDE QUINOLINES AS NK-3 RECEPTOR LIGANDS | Astra Zeneca AB (SE) | 2008-06-11 | — | — | EP | claimed |
| WO-2007035158-A1 | ALKYL SULFOXIDE QUINOLINES AS NK-3 RECEPTOR LIGANDS | ASTRAZENECA AB (SE) | 2007-03-29 | — | — | WO | claimed |