Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 12/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | IGF1R | P08069 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.38 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.38 |
| ▸ | SLC6A9 | P48067 | 2/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27402701 | 0.78 | MEN1 (0.51) | OPRD1MEN1KMT2AOPRM1 | |
| SCHEMBL8051571 | 0.75 | MEN1 (0.47) | OPRD1MEN1KMT2AOPRM1 | |
| SCHEMBL9684251 | 0.75 | ALDH1A1 (0.44) | OPRD1KMT2AOPRM1OPRK1OPRL1 | |
| SCHEMBL9842210 | 0.74 | OPRD1 (0.38) | OPRD1MEN1KMT2AOPRM1OPRK1 | |
| SCHEMBL9842205 | 0.73 | OPRD1 (0.43) | OPRD1MEN1KMT2AOPRM1OPRK1 | |
| SCHEMBL9842287 | 0.73 | OPRD1 (0.39) | OPRD1MEN1KMT2AOPRM1OPRK1 | |
| SCHEMBL6634453 | 0.73 | HRH1 (0.54) | OPRD1OPRM1OPRK1OPRL1SLC6A9 | |
| SCHEMBL4275538 | 0.72 | MEN1 (0.44) | OPRD1MEN1KMT2AOPRM1OPRK1 | |
| SCHEMBL5633854 | 0.70 | OPRD1 (0.50) | OPRD1MEN1KMT2AOPRM1NPSR1 | |
| Hydrochloric Acid SCHEMBL8693224 | 0.70 | MEN1 (0.42) | OPRD1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2041088-A1 | GLYCINE TRANSPORTER-1 INHIBITORS | Amgen Inc. (US) | 2009-04-01 | — | — | EP | claimed |
| WO-2008002583-A1 | GLYCINE TRANSPORTER-1 INHIBITORS | AMGEN INC. (US) | 2008-01-03 | — | — | WO | claimed |