Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 8/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL306690 | 0.82 | P2RX7 (0.49) | P2RX7L3MBTL1ROCK2EPHX2NPC1 | |
| SCHEMBL4443575 | 0.78 | P2RX7 (0.55) | P2RX7L3MBTL1ALDH1A1KMT2AHTT | |
| SCHEMBL4440942 | 0.77 | P2RX7 (0.57) | P2RX7ALDH1A1 | |
| SCHEMBL4440132 | 0.75 | P2RX7 (0.61) | P2RX7SHMT2 | |
| SCHEMBL4442126 | 0.74 | P2RX7 (0.55) | P2RX7ALDH1A1KMT2A | |
| SCHEMBL308276 | 0.72 | P2RX7 (0.55) | P2RX7EPHX2RAB9AALDH1A1KMT2A | |
| SCHEMBL307169 | 0.72 | P2RX7 (0.55) | P2RX7EPHX2RAB9AALDH1A1KMT2A | |
| SCHEMBL4441990 | 0.71 | P2RX7 (0.76) | P2RX7 | |
| SCHEMBL4442516 | 0.71 | P2RX7 (0.76) | P2RX7 | |
| SCHEMBL4442055 | 0.71 | DPP4 (0.35) | P2RX7ALDH1A1SHMT2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2124562-A1 | BICYCLOHETEROARYL COMPOUNDS AS P2X7 MODULATORS AND USES THEREOF | Renovis, Inc. (US) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008112205-A1 | BICYCLOHETEROARYL COMPOUNDS AS P2X7 MODULATORS AND USES THEREOF | RENOVIS, INC. (US) | 2008-09-18 | — | — | WO | disclosed |