Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 2/20 | 0.31 |
| ▸ | FAAH | O00519 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.31 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.31 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.31 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.31 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.31 |
| ▸ | HTR2B | P41595 | 1/20 | 0.31 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.31 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4443526 | 0.73 | CA4 (0.30) | — | |
| Hydrochloric Acid SCHEMBL394796 | 0.71 | TSHR (0.31) | TSHRFAAHCA1CA2LMNA | |
| Hydrochloric Acid SCHEMBL29556368 | 0.69 | TSHR (0.34) | TSHRFAAHCA1CA2LMNA | |
| SCHEMBL5709976 | 0.69 | FAAH (0.32) | TSHRFAAHCA1CA2LMNA | |
| Hydrochloric Acid SCHEMBL4449809 | 0.68 | GABRA1 (0.32) | TSHRFAAHCA1CA2LMNA | |
| Hydrochloric Acid SCHEMBL394797 | 0.68 | SCN5A (0.32) | TSHRFAAHCA1CA2LMNA | |
| Hydrochloric Acid SCHEMBL28592292 | 0.66 | — | — | |
| Hydrochloric Acid SCHEMBL30697857 | 0.65 | GABRA1 (0.36) | TSHRFAAHCA1CA2LMNA | |
| Hydrochloric Acid SCHEMBL715702 | 0.65 | GABRA1 (0.33) | TSHRFAAHCA1CA2LMNA | |
| Hydrochloric Acid SCHEMBL9565693 | 0.62 | GABRA1 (0.44) | TSHRFAAHCA1CA2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3438183-B1 | POLYETHYLENE AND MOLDED BODY THEREOF | JAPAN POLYETHYLENE CORP (JP) | 2023-11-22 | — | — | EP | disclosed |
| US-10377886-B2 | Polyethylene for pipe and joint, and molded body thereof | JAPAN POLYETHYLENE CORPORATION (JP) | 2019-08-13 | — | — | US | disclosed |
| US-20190136021-A1 | POLYETHYLENE AND MOLDED BODY THEREOF | JAPAN POLYETHYLENE CORPORATION (JP) | 2019-05-09 | — | — | US | disclosed |
| EP-3438183-A1 | POLYETHYLENE AND MOLDED BODY OF SAME | Japan Polypropylene Corporation (JP) | 2019-02-06 | — | — | EP | disclosed |
| US-20180112070-A1 | POLYETHYLENE FOR PIPE AND JOINT, AND MOLDED BODY THEREOF | JAPAN POLYETHYLENE CORPORATION (JP) | 2018-04-26 | — | — | US | disclosed |
| EP-1247573-B1 | Catalyst for polymerizing olefin and process for polymerizing olefin | JAPAN POLYPROPYLENE CORP (JP) | 2009-10-21 | — | — | EP | disclosed |
| EP-1160261-B1 | Olefin polymerization catalyst and method for polymerizing olefin using the same | JAPAN POLYCHEM CORP (JP) | 2007-06-27 | — | — | EP | disclosed |
| US-7005400-B2 | Component of catalyst for polymerizing olefin, catalyst for polymerizing olefin and process for polymerizing olefin | JAPAN POLYCHEM CORPORATION (JP) | 2006-02-28 | — | — | US | disclosed |
| EP-1247573-A1 | Component of catalyst for polymerizing olefin, catalyst for polymerizing olefin and process for polymerizing olefin | Japan Polychem Corporation, Catalyst Research & Development Center (JP) | 2002-10-09 | — | — | EP | disclosed |
| EP-1160261-A1 | Olefin polymerization catalyst and method for polymerizing olefin using the same | Japan Polychem Corporation (JP) | 2001-12-05 | — | — | EP | disclosed |