Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.61 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.58 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | NAMPT | P43490 | 1/20 | 0.49 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | FAAH | O00519 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL28059160 | 0.98 | ALDH1A1 (0.59) | ALDH1A1CYP17A1CYP19A1KMT2ALMNA | |
| SCHEMBL8635320 | 0.87 | HSD11B1 (0.51) | ALDH1A1CYP17A1CYP19A1KMT2ALMNA | |
| SCHEMBL4245622 | 0.85 | KMT2A (0.58) | ALDH1A1CYP17A1CYP19A1KMT2ALMNA | |
| SCHEMBL28711108 | 0.85 | KMT2A (0.58) | ALDH1A1CYP17A1CYP19A1KMT2ALMNA | |
| SCHEMBL4245629 | 0.84 | KMT2A (0.61) | ALDH1A1CYP17A1CYP19A1KMT2ALMNA | |
| SCHEMBL12230963 | 0.84 | KMT2A (0.57) | ALDH1A1CYP17A1CYP19A1KMT2ALMNA | |
| SCHEMBL11256172 | 0.83 | KMT2A (0.53) | ALDH1A1CYP17A1CYP19A1KMT2ALMNA | |
| Pyridine SCHEMBL4372448 | 0.82 | ALDH1A1 (0.79) | ALDH1A1KMT2ALMNATDP1 | |
| SCHEMBL2519199 | 0.82 | ALDH1A1 (0.61) | ALDH1A1CYP17A1CYP19A1KMT2ALMNA | |
| SCHEMBL4667872 | 0.82 | KMT2A (0.55) | ALDH1A1CYP17A1CYP19A1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0060994-A1 | Bis-hydroxyethylmercapto-1,10-decane derivative, process for its preparation, and pharmaceutical compositions containing it | LABORATORI PROPHIN S.p.A. (IT) | 1982-09-29 | — | — | EP | claimed |
| EP-2613775-B1 | N-HYDROXY-BENZAMIDES FOR THE TREATMENT OF CANCER | HOFFMANN LA ROCHE (CH) | 2014-07-30 | — | — | EP | disclosed |
| US-8716285-B2 | N-hydroxy-benzamids for the treatment of cancer | HOFFMANN-LA ROCHE INC. (US) | 2014-05-06 | — | — | US | disclosed |
| EP-2613775-A1 | NOVEL N-HYDROXY-BENZAMIDES FOR THE TREATMENT OF CANCER | F.HOFFMANN-LA ROCHE AG (CH) | 2013-07-17 | — | — | EP | disclosed |
| US-20120065204-A1 | NOVEL N-HYDROXY-BENZAMIDS FOR THE TREATMENT OF CANCER | F. HOFFMANN-LA ROCHE AG (CH) | 2012-03-15 | — | — | US | disclosed |
| WO-2012031993-A1 | NOVEL N-HYDROXY-BENZAMIDES FOR THE TREATMENT OF CANCER | F. HOFFMANN-LA ROCHE AG (CH) | 2012-03-15 | — | — | WO | disclosed |
| US-6323212-B1 | METHOD FOR REDUCING PAIN, WHICH COMPRISES ADMINISTERING AN EFFECTIVE ANALGESIC AMOUNT OF THE MORPHINAN DERIVATIVE | TORAY INDUSTRIES, INC. (JP) | 2001-11-27 | — | — | US | disclosed |
| US-6277859-B1 | HIGHLY SELECTIVE KAPPA-OPIOID AGONISTS USEFUL AS ANALGESICS AND DIURETICS WITH REDUCED PHYSIOLOGICAL SIDE EFFECTS | TORAY INDUSTRIES, INC. (JP) | 2001-08-21 | — | — | US | disclosed |
| US-6177438-B1 | ANALGESICS, DIURETICS, ANTITUSSIVE AGENTS | TORAY INDUSTRIES, INC. (JP) | 2001-01-23 | — | — | US | disclosed |
| EP-0577847-B1 | MORPHINAN DERIVATIVE AND MEDICINAL USE | TORAY INDUSTRIES (JP) | 1998-10-14 | — | — | EP | disclosed |
| EP-0846694-A1 | Morphinan derivative and its pharmaceutical applications | TORAY INDUSTRIES, INC. (JP) | 1998-06-10 | — | — | EP | disclosed |
| EP-0663401-A1 | MORPHINAN DERIVATIVE AND MEDICINAL USE | TORAY INDUSTRIES, INC. (JP) | 1995-07-19 | — | — | EP | disclosed |
| EP-0577847-A1 | MORPHINAN DERIVATIVE AND MEDICINAL USE | TORAY INDUSTRIES, INC. (JP) | 1994-01-12 | — | — | EP | disclosed |
| EP-0060994-A1 | Bis-hydroxyethylmercapto-1,10-decane derivative, process for its preparation, and pharmaceutical compositions containing it | LABORATORI PROPHIN S.p.A. (IT) | 1982-09-29 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120065204-A1 | NOVEL N-HYDROXY-BENZAMIDS FOR THE TREATMENT OF CANCER | HNMT, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, HRAS | ALDH1A1 158/4885CYP17A1 1535/4885CYP19A1 840/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.