Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Clobetasol Propionate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 known ✓ | P04150 | 6/20 | 1.00 |
| ▸ | PGR | P06401 | 6/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 5/20 | 1.00 |
| ▸ | USP2 | O75604 | 5/20 | 1.00 |
| ▸ | LMNA | P02545 | 3/20 | 1.00 |
| ▸ | MAPT | P10636 | 3/20 | 1.00 |
| ▸ | NR1I2 | O75469 | 2/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 1.00 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 1.00 |
| ▸ | MLNR | O43193 | 1/20 | 1.00 |
| ▸ | ABCB11 | O95342 | 1/20 | 1.00 |
| ▸ | CYP3A5 | P20815 | 1/20 | 1.00 |
| ▸ | PPARG | P37231 | 1/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 1/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 1/20 | 1.00 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.84 |
| ▸ | DRD2 | P14416 | 1/20 | 0.84 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.84 |
| ▸ | MEN1 | O00255 | 1/20 | 0.75 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.75 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Clobetasol Propionate SCHEMBL5577907 | 1.00 | PGR (1.00) | PGRNR3C1CYP3A4USP2LMNA | |
| Clobetasol Propionate SCHEMBL17131797 | 1.00 | PGR (1.00) | PGRNR3C1CYP3A4USP2LMNA | |
| Clobetasol Propionate SCHEMBL3997 | 1.00 | PGR (1.00) | PGRNR3C1CYP3A4USP2LMNA | |
| Clobetasol Propionate SCHEMBL11052078 | 1.00 | PGR (1.00) | PGRNR3C1CYP3A4USP2LMNA | |
| Clobetasol Propionate SCHEMBL11052079 | 1.00 | PGR (1.00) | PGRNR3C1CYP3A4USP2LMNA | |
| Clobetasol Propionate SCHEMBL5577908 | 1.00 | PGR (1.00) | PGRNR3C1CYP3A4USP2LMNA | |
| Clobetasol Propionate SCHEMBL10865006 | 1.00 | PGR (1.00) | PGRNR3C1CYP3A4USP2LMNA | |
| Clobetasol Propionate SCHEMBL28118983 | 0.98 | NR3C1 (0.95) | PGRNR3C1CYP3A4USP2LMNA | |
| Betamethasone Dipropionate SCHEMBL18301225 | 0.95 | NR3C1 (0.93) | PGRNR3C1CYP3A4USP2LMNA | |
| SCHEMBL596943 | 0.94 | NR3C1 (0.88) | PGRNR3C1CYP3A4USP2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 2073 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4255391-B1 | LUMINOL FOR USE IN THE TREATMENT OF SEQUELAE OF A SARS-COV-2 INFECTION | METRIOPHARM AG (CH) | 2026-05-06 | — | — | EP | claimed |
| EP-4301343-B1 | PHARMACEUTICAL COMPOSITIONS WITH REDUCED SIDE EFFECT AND METHODS OF USING THE SAME | TLC BIOPHARMACEUTICALS INC (US) | 2025-11-19 | — | — | EP | claimed |
| EP-4178579-B1 | 5-AMINO-2,3-DIHYDRO-1,4-PHTHALAZINEDIONE AS GLUCOCORTICOID-SPARING AGENT | METRIOPHARM AG (CH) | 2025-02-12 | — | — | EP | claimed |
| EP-3773563-B1 | PRODRUGS OF FUSED-BICYCLIC C5AR ANTAGONISTS | CHEMOCENTRYX INC (US) | 2024-10-16 | — | — | EP | claimed |
| US-20240156839-A1 | PHARMACEUTICAL COMPOSITIONS WITH REDUCED SIDE EFFECT AND METHODS OF USING THE SAME | TLC BIOPHARMACEUTICALS, INC. | 2024-05-16 | — | — | US | claimed |
| EP-3728203-B1 | DIARYL SUBSTITUTED 6,5-FUSED RING COMPOUNDS AS C5aR INHIBITORS | CHEMOCENTRYX INC (US) | 2024-03-13 | — | — | EP | claimed |
| EP-4301343-A1 | PHARMACEUTICAL COMPOSITIONS WITH REDUCED SIDE EFFECT AND METHODS OF USING THE SAME | TLC Biopharmaceuticals, Inc. (US) | 2024-01-10 | — | — | EP | claimed |
| WO-2023183932-A2 | MONOBODIES BINDING TO INTERCELLULAR ADHESION MOLECULE 2 (ICAM-2) | NEW YORK UNIVERSITY (US) | 2023-09-28 | — | — | WO | claimed |
| US-20230241060-A1 | GLUCOCORTICOID-SPARING AGENT | METRIOPHARM AG (CH) | 2023-08-03 | — | — | US | claimed |
| EP-4178579-A1 | GLUCOCORTICOID-SPARING AGENT | MetrioPharm AG (CH) | 2023-05-17 | — | — | EP | claimed |
| EP-1758591-B1 | INVERT EMULSION COMPOSITION CONTAINING CALCITRIOL AND CLOBETASOL 17-PROPIONATE, AND USES THEREOF IN COSMETICS AND DERMATOLOGY | GALDERMA SA (CH) | 2007-10-10 | — | — | EP | claimed |
| WO-2007012977-A2 | STEROID KIT AND FOAMABLE COMPOSITION AND USES THEREOF | FOAMIX LTD (US) | 2007-02-01 | — | — | WO | claimed |
| WO-2006131401-A2 | CONTROLLED RELEASE OF A DRUG THROUGH SKIN ON THE BASIS OF A TOPICAL COMPOSITION COMPRISING A DRUG, A FILM-FORMING SILICONE AND AT LEAST ONE VOLATILE SOLVENT | GALDERMA S.A. (CH) | 2006-12-14 | — | — | WO | claimed |
| US-20060193789-A1 | Surfacant, film forming agent, water, gas propellant; plant and animal extracts and oils; may include malathion | FOAMIX LTD. (IL) | 2006-08-31 | — | — | US | claimed |
| US-20060018937-A1 | Steroid kit and foamable composition and uses thereof | FOAMIX LTD. | 2006-01-26 | — | — | US | claimed |
| EP-1496895-B1 | USE OF CYCLOPAMINE IN THE TREATMENT OF PSORIASIS AND OTHER SKIN DISORDERS | TAS SINAN (TR) | 2005-11-16 | — | — | EP | claimed |
| EP-1087747-B1 | FOAMING COMPOSITION FOR HAIR CARE | GALDERMA SA (CH) | 2005-11-09 | — | — | EP | claimed |
| EP-1205218-B1 | Topical antipsoriaticum comprising urea, a corticoid and a desinfectant | BENKERT EUGEN GEORG DR MED DEN (DE) | 2004-03-31 | — | — | EP | claimed |
| EP-1205218-A1 | Topical antipsoriaticum comprising urea, a corticoid and a desinfectant | Benkert, Eugen Georg, Dr.med.dent. (DE) | 2002-05-15 | — | — | EP | claimed |
| EP-0484529-B1 | SKIN CREAM PREPARATION FOR EXTERNAL USE | HISAMITSU PHARMACEUTICAL CO (JP) | 1994-04-27 | — | — | EP | claimed |