Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 5/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.36 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | SLC5A7 | Q9GZV3 | 1/20 | 0.36 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | ACACB | O00763 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3954661 | 0.78 | MDM2 (0.42) | SCN9AKCNH2SCN5A | |
| SCHEMBL4334649 | 0.76 | SCN9A (0.64) | SCN9AKCNH2SCN5A | |
| SCHEMBL4334652 | 0.66 | SCN9A (0.54) | SCN9AKCNH2SCN5A | |
| SCHEMBL31591606 | 0.64 | LOX (0.43) | LNPEPKCNH2ACACB | |
| SCHEMBL4342306 | 0.64 | LOX (0.43) | LNPEPKCNH2ACACB | |
| SCHEMBL3961394 | 0.62 | SCN9A (0.53) | SCN9AKCNH2SCN5ACYP3A4 | |
| SCHEMBL12367594 | 0.59 | LIPE (0.41) | — | |
| SCHEMBL5531111 | 0.59 | ALDH1A1 (0.58) | KCNH2SLC5A7L3MBTL1 | |
| SCHEMBL13568301 | 0.56 | SCN9A (0.58) | SCN9AKCNH2SCN5AL3MBTL1 | |
| SCHEMBL4461400 | 0.56 | SCN9A (0.60) | SCN9AKCNH2SCN5ACYP2D6L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009145720-A1 | ISOINDOLINE DERIVATIVES COMPRISING ADDITIONAL HETEROCYCLIC GROUPS AND THEIR USE IN THE TREATMENT OF PAIN DISORDERS | ASTRAZENECA AB (SE) | 2009-12-03 | — | — | WO | disclosed |