SCHEMBL4453366

SCHEMBL4453366

Clc1ccc(Cl)c(-c2c(Cl)c(Cl)cc(Cl)c2Cl)c1

nearest known ligand 0.46

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
TP53 P04637 3/20 0.46
AHR P35869 4/20 0.45
HTR2B P41595 1/20 0.44
PDE4D Q08499 1/20 0.44
ALDH1A1 P00352 5/20 0.43
CNR2 P34972 1/20 0.42
PTPN11 Q06124 1/20 0.41
IDO1 P14902 1/20 0.41
TSHR P16473 2/20 0.41
CYP3A4 P08684 2/20 0.41
HSD17B10 Q99714 1/20 0.41
TDP1 Q9NUW8 1/20 0.41
RXFP1 Q9HBX9 1/20 0.40
S100A4 P26447 1/20 0.39
MAPT P10636 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4445059 0.88 TP53 (0.48) TP53AHRHTR2BPDE4DALDH1A1
SCHEMBL4459784 0.86 TP53 (0.42) TP53AHRHTR2BPDE4DALDH1A1
SCHEMBL4450570 0.86 TP53 (0.46) TP53AHRHTR2BPDE4DALDH1A1
SCHEMBL29618916 0.86 TP53 (0.46) TP53AHRHTR2BPDE4DALDH1A1
SCHEMBL4454535 0.81 TP53 (0.52) TP53AHRHTR2BPDE4DALDH1A1
SCHEMBL4459802 0.81 AHR (0.61) TP53AHRALDH1A1TSHRCYP3A4
SCHEMBL29489601 0.80 TP53 (0.57) TP53AHRHTR2BPDE4DALDH1A1
SCHEMBL2852592 0.80 TP53 (0.57) TP53AHRHTR2BPDE4DALDH1A1
SCHEMBL440944 0.79 TP53 (0.61) TP53AHRHTR2BPDE4DALDH1A1
SCHEMBL29364307 0.79 TP53 (0.61) TP53AHRHTR2BPDE4DALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220351865-A1 METHODS OF BIOLOGICAL AGE EVALUATION AND SYSTEMS USING SUCH METHODS GERO PTE. LTD. (SG) 2022-11-03 US claimed
EP-3881907-A1 METHOD FOR DECHLORINATION OF ONE OR MORE AROMATIC ORGANOCHLORINE COMPOUND(S) CONTAINED IN AN OIL OR FORMING SAID OIL - ASSOCIATED ELECTRICAL/ELECTRONIC DEVICE AND INSTALLATION Université de Lille (FR) 2021-09-22 EP claimed
CN-109191651-B Internet of things administrative lock and control system thereof 暨芯集成电路产业研究院 2024-08-13 CN disclosed
CN-117317722-B Pop-up plug 合肥中科微保可穿戴科技有限公司 2024-03-26 CN disclosed
CN-117317722-A Pop-up plug 合肥中科微保可穿戴科技有限公司 2023-12-29 CN disclosed
CN-111701144-B Systems and methods for phototherapy modulation of nitric oxide 诺欧生物有限责任公司 2023-03-21 CN disclosed
US-20230047816-A1 PFKFB3 INHIBITORS AND THEIR USES GERO PTE. LTD. (SG) 2023-02-16 US disclosed
US-20220351865-A1 METHODS OF BIOLOGICAL AGE EVALUATION AND SYSTEMS USING SUCH METHODS GERO PTE. LTD. (SG) 2022-11-03 US disclosed
CN-113286060-B Monitoring camera with heater 安讯士有限公司 2022-10-11 CN disclosed
US-20220227679-A1 COMPOSITION FOR COATING SUBSTRATES TRADE CORPORATION INTERNATIONAL, S.A. UNIPERSONAL (ES) 2022-07-21 US disclosed
EP-3976557-A1 COMPOSITION FOR COATING SUBSTRATES Trade Corporation International, S.A. Unipersonal (ES) 2022-04-06 EP disclosed
CN-216015541-U Energy storage module 上海派能能源科技股份有限公司 2022-03-11 CN disclosed
EP-3881907-A1 METHOD FOR DECHLORINATION OF ONE OR MORE AROMATIC ORGANOCHLORINE COMPOUND(S) CONTAINED IN AN OIL OR FORMING SAID OIL - ASSOCIATED ELECTRICAL/ELECTRONIC DEVICE AND INSTALLATION Université de Lille (FR) 2021-09-22 EP disclosed
CN-111768814-A Method for predicting POM-water distribution coefficient of organic pollutant based on quantitative structure-activity relationship 扬州大学 2020-10-13 CN disclosed
US-20090269857-A1 Instruments for detecting low-molecular weight substance FUJIKURA KASEI CO., LTD. (JP) 2009-10-29 US disclosed
US-20050148097-A1 Instruments for detecting low-molecular weight substance ENBIOTEC LABORATORIES C., LTD. (JP) 2005-07-07 US disclosed
EP-1489420-A1 INSTRUMENTS FOR DETECTING LOW-MOLECULAR WEIGHT SUBSTANCE Enbiotec Laboratories Co., Ltd. (JP) 2004-12-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230047816-A1 PFKFB3 INHIBITORS AND THEIR USES PFKFB3, PFKFB4, PFKFB1 TP53 2372/4885AHR 3353/4885HTR2B 4156/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.