Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4462541 | 0.84 | DHFR (0.43) | DHFR | |
| SCHEMBL4472365 | 0.82 | DHFR (0.39) | DHFR | |
| SCHEMBL1791868 | 0.79 | NOTUM (0.52) | — | |
| SCHEMBL4462500 | 0.76 | KDM4E (0.45) | DHFR | |
| SCHEMBL1794999 | 0.73 | DHFR (0.49) | DHFR | |
| SCHEMBL4458392 | 0.70 | DHFR (0.51) | DHFR | |
| SCHEMBL4462978 | 0.66 | ALDH1A1 (0.51) | — | |
| SCHEMBL315996 | 0.64 | HSP90AA1 (0.52) | — | |
| SCHEMBL4468493 | 0.64 | IGF1R (0.33) | — | |
| SCHEMBL3962268 | 0.62 | DHFR (0.60) | DHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009017838-A2 | COMBINATIONS OF JAK-2 INHIBITORS AND OTHER AGENTS | EXELIXIS, INC. (US) | 2009-02-05 | — | — | WO | claimed |