Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.55 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | PSMB11 | A5LHX3 | 1/20 | 0.52 |
| ▸ | PSMA7 | O14818 | 1/20 | 0.52 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.52 |
| ▸ | PSMA1 | P25786 | 1/20 | 0.52 |
| ▸ | PSMA2 | P25787 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22757714 | 0.94 | ALDH1A1 (0.55) | SMN1; SMN2KDM4EHPGDLMNACYP1A2 | |
| SCHEMBL25718613 | 0.84 | SMN1; SMN2 (0.58) | SMN1; SMN2KDM4EHPGDLMNACYP1A2 | |
| SCHEMBL27890663 | 0.83 | KDM4E (0.61) | SMN1; SMN2KDM4EHPGDLMNACYP1A2 | |
| SCHEMBL31285763 | 0.80 | KDM4E (0.67) | SMN1; SMN2KDM4EHPGDLMNAKMT2A | |
| SCHEMBL10674362 | 0.80 | KDM4E (0.67) | SMN1; SMN2KDM4EHPGDLMNACYP1A2 | |
| SCHEMBL10668907 | 0.80 | SMN1; SMN2 (0.61) | SMN1; SMN2KDM4EHPGDLMNACYP1A2 | |
| SCHEMBL509136 | 0.80 | SMN1; SMN2 (0.61) | SMN1; SMN2KDM4EHPGDLMNACYP1A2 | |
| SCHEMBL10671618 | 0.80 | SMN1; SMN2 (0.61) | SMN1; SMN2KDM4EHPGDLMNACYP1A2 | |
| SCHEMBL2215871 | 0.80 | KDM4E (0.67) | SMN1; SMN2KDM4EHPGDLMNACYP1A2 | |
| SCHEMBL28092442 | 0.80 | SMN1; SMN2 (0.61) | SMN1; SMN2KDM4EHPGDLMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4079748-A1 | MODULATORS OF SORTILIN ACTIVITY | Insusense ApS (DK) | 2022-10-26 | — | — | EP | disclosed |
| US-20160250237-A1 | SOFT PROTEASE INHIBITORS AND PRO-SOFT FORMS THEREOF | BACH BIOSCIENCES, LLC | 2016-09-01 | — | — | US | disclosed |
| US-9192646-B2 | Soft protease inhibitors and pro-soft forms thereof | TRUSTEES OF TUFTS COLLEGE (US) | 2015-11-24 | — | — | US | disclosed |
| US-20150157684-A1 | Soft Protease Inhibitors and Pro-Soft Forms Thereof | BACH BIOSCIENCES, LLC | 2015-06-11 | — | — | US | disclosed |
| US-8933056-B2 | Soft protease inhibitors and pro-soft forms thereof | TRUSTEES OF TUFTS COLLEGE (US) | 2015-01-13 | — | — | US | disclosed |
| US-20140128344-A1 | Soft Protease Inhibitors and Pro-Soft Forms Thereof | TRUSTEES OF TUFTS COLLEGE (US) | 2014-05-08 | — | — | US | disclosed |
| US-8563533-B2 | Soft protease inhibitors and pro-soft forms thereof | TRUSTEES OF TUFTS COLLEGE (US) | 2013-10-22 | — | — | US | disclosed |
| US-20130150292-A1 | Soft Protease Inhibitors and Pro-Soft Forms Thereof | TRUSTEES OF TUFTS COLLEGE (US) | 2013-06-13 | — | — | US | disclosed |
| US-8268880-B2 | Soft protease inhibitors and pro-soft forms thereof | TRUSTEES OF TUFTS COLLEGE (US) | 2012-09-18 | — | — | US | disclosed |
| US-20090124559-A1 | Soft Protease Inhibitors and Pro-Soft Forms Thereof | TRUSTEES OF TUFTS COLLEGE OFFICE OF TECHNOLOGY AND INDUSTRY COLLABORATION (US) | 2009-05-14 | — | — | US | disclosed |
| US-20040127506-A1 | Antimycobacterial compounds | YATVIN MILTON B (US) | 2004-07-01 | — | — | US | disclosed |
| US-6664257-B2 | Such as derivatives of n-butyl-pyrazinamide for treatment of tuberculosis | ENZREL INC. | 2003-12-16 | — | — | US | disclosed |
| US-20030100569-A1 | Anti-mycobacterial compounds | ENZREL INC. | 2003-05-29 | — | — | US | disclosed |
| WO-2003039457-A2 | ANTI-MYCOBACTERIAL COMPOUNDS | ENZREL, INC (US) | 2003-05-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130150292-A1 | Soft Protease Inhibitors and Pro-Soft Forms Thereof | PREP, DPP4, PEPD | SMN1; SMN2 1442/4885KDM4E 478/4885HPGD 4011/4885 |
| US-20040127506-A1 | Antimycobacterial compounds | IMMT, MT-ND5, ACAT1 | SMN1; SMN2 4298/4885KDM4E 3140/4885HPGD 1377/4885 |
| US-20090124559-A1 | Soft Protease Inhibitors and Pro-Soft Forms Thereof | PREP, DPP4, PEPD | SMN1; SMN2 1442/4885KDM4E 478/4885HPGD 4011/4885 |
| US-20160250237-A1 | SOFT PROTEASE INHIBITORS AND PRO-SOFT FORMS THEREOF | PREP, DPP4, PEPD | SMN1; SMN2 1442/4885KDM4E 478/4885HPGD 4011/4885 |
| US-20150157684-A1 | Soft Protease Inhibitors and Pro-Soft Forms Thereof | PREP, DPP4, PEPD | SMN1; SMN2 1442/4885KDM4E 478/4885HPGD 4011/4885 |
| US-20030100569-A1 | Anti-mycobacterial compounds | IMMT, PML, TBC1D5 | SMN1; SMN2 4267/4885KDM4E 2628/4885HPGD 1292/4885 |
| US-20140128344-A1 | Soft Protease Inhibitors and Pro-Soft Forms Thereof | PREP, DPP4, PEPD | SMN1; SMN2 1442/4885KDM4E 478/4885HPGD 4011/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.