Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Di(Hydroxyethyl)Ether. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | TSHR | P16473 | 3/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | THRB | P10828 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.34 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.34 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | FYN | P06241 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
| ▸ | CES2 | O00748 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Di(Hydroxyethyl)Ether SCHEMBL5071580 | 0.88 | ALDH1A1 (0.62) | ALDH1A1TSHRMAPK1KMT2AMEN1 | |
| Di(Hydroxyethyl)Ether SCHEMBL1561767 | 0.87 | TSHR (0.56) | ALDH1A1TSHRMAPK1KMT2AMEN1 | |
| Di(Hydroxyethyl)Ether SCHEMBL271069 | 0.87 | TSHR (0.62) | ALDH1A1TSHRMAPK1KMT2AMEN1 | |
| Di(Hydroxyethyl)Ether SCHEMBL141391 | 0.87 | ALDH1A1 (0.67) | ALDH1A1TSHRMAPK1KMT2AMEN1 | |
| Di(Hydroxyethyl)Ether SCHEMBL27615302 | 0.87 | TSHR (0.62) | ALDH1A1TSHRMAPK1KMT2AMEN1 | |
| Di(Hydroxyethyl)Ether SCHEMBL28435040 | 0.87 | TSHR (0.62) | ALDH1A1TSHRMAPK1KMT2AMEN1 | |
| Di(Hydroxyethyl)Ether SCHEMBL36022 | 0.87 | TSHR (0.62) | ALDH1A1TSHRMAPK1KMT2AMEN1 | |
| Di(Hydroxyethyl)Ether SCHEMBL4528960 | 0.87 | TSHR (0.62) | ALDH1A1TSHRMAPK1KMT2AMEN1 | |
| Di(Hydroxyethyl)Ether SCHEMBL9325783 | 0.87 | TSHR (0.62) | ALDH1A1TSHRMAPK1KMT2AMEN1 | |
| Di(Hydroxyethyl)Ether SCHEMBL8642258 | 0.87 | TSHR (0.62) | ALDH1A1TSHRMAPK1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116709723-A | Radiating plate, method of manufacturing the same, and image display apparatus including the same | 东友精细化工有限公司 | 2023-09-05 | — | — | CN | disclosed |
| CN-107203096-B | Negative photosensitive resin composition and photocured pattern made therefrom | 东友精细化工有限公司 | 2020-07-10 | — | — | CN | disclosed |
| CN-111334157-A | Powder coating for wooden furniture and preparation method thereof | 安徽华辉塑业科技股份有限公司 | 2020-06-26 | — | — | CN | disclosed |
| CN-104194423-A | Fireproof coating for wooden furniture and preparation method thereof | SUZHOU SHENGPULA NEW MATERIAL TECHNOLOGY CO LTD | 2014-12-10 | — | — | CN | disclosed |
| CN-102725679-A | Liquid crystal aligning agent and liquid crystal display element using same | NISSAN CHEMICAL IND LTD | 2012-10-10 | — | — | CN | disclosed |
| US-20090026425-A1 | COMPOSITION COMPRISING POLYESTER AMIDE ACID AND THE LIKE AND INK-JET INK COMPOSITION USING THE SAME | CHISSO CORPORATION (JP) | 2009-01-29 | — | — | US | disclosed |