Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HCAR1 | Q9BXC0 | 4/20 | 0.40 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.38 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.38 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.38 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CASP6 | P55212 | 1/20 | 0.36 |
| ▸ | LIG1 | P18858 | 1/20 | 0.35 |
| ▸ | LIG3 | P49916 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4454027 | 0.95 | ALDH1A1 (0.41) | ALDH1A1KDM4ESMN1; SMN2HCAR1PDE7A | |
| SCHEMBL4498921 | 0.83 | ALDH1A1 (0.48) | ALDH1A1KDM4ESMN1; SMN2HCAR1PDE7A | |
| SCHEMBL4454520 | 0.81 | MAPT (0.47) | ALDH1A1KDM4EHPGDKMT2AMAPT | |
| SCHEMBL15330466 | 0.78 | ALDH1A1 (0.44) | ALDH1A1KDM4ESMN1; SMN2HCAR1PDE7A | |
| SCHEMBL4492126 | 0.78 | MAPT (0.47) | ALDH1A1KDM4ESMN1; SMN2GRIN2DGRIN3B | |
| SCHEMBL4501815 | 0.77 | MEN1 (0.47) | ALDH1A1KDM4EHPGDKMT2AMAPT | |
| SCHEMBL4458183 | 0.76 | GRIN2D (0.38) | KDM4EGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL4465222 | 0.74 | MAPT (0.43) | ALDH1A1KDM4ESMN1; SMN2GRIN2DGRIN3B | |
| SCHEMBL4471023 | 0.74 | MEN1 (0.44) | ALDH1A1KDM4EHPGDKMT2AMAPT | |
| SCHEMBL4502462 | 0.71 | ALDH1A1 (0.69) | ALDH1A1KDM4EHCAR1PDE7AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090286813-A1 | Thioxanthine Derivatives and Their Use as Inhibitors of MPO | ASTRAZENECA AB (SE) | 2009-11-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090286813-A1 | Thioxanthine Derivatives and Their Use as Inhibitors of MPO | MPO, XDH, EPX | ALDH1A1 296/4885KDM4E 3612/4885SMN1; SMN2 1754/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.