Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NNMT | P40261 | 4/20 | 0.40 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.38 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1126374 | 0.81 | LMNA (0.36) | HRH3KDM4EALDH1A1 | |
| SCHEMBL4465211 | 0.79 | HRH3 (0.48) | NNMTPRMT5WDR77HRH3SMN1; SMN2 | |
| SCHEMBL3317954 | 0.79 | GRM2 (0.39) | HRH3CHEK1MAP3K11 | |
| SCHEMBL4465984 | 0.78 | OPRM1 (0.41) | NNMTPRMT5WDR77HRH3SMN1; SMN2 | |
| SCHEMBL3318357 | 0.74 | PARP1 (0.32) | — | |
| SCHEMBL4463539 | 0.72 | FGFR3 (0.44) | NNMTPRMT5WDR77HRH3SMN1; SMN2 | |
| SCHEMBL23103266 | 0.72 | HRH3 (0.42) | PRMT5WDR77HRH3KDM4E | |
| SCHEMBL15251306 | 0.72 | HRH3 (0.57) | NNMTPRMT5WDR77HRH3SMN1; SMN2 | |
| SCHEMBL4452722 | 0.71 | HRH3 (0.48) | NNMTPRMT5WDR77HRH3SMN1; SMN2 | |
| SCHEMBL27815604 | 0.71 | HRH3 (0.61) | NNMTPRMT5WDR77HRH3SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009141386-A1 | DERIVATIVES OF QUINOLINES AND QUINOXALINES AS PROTEIN TYROSINE KINASE INHIBITORS | NOVARTIS AG (CH) | 2009-11-26 | — | — | WO | disclosed |