Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 6/20 | 0.70 |
| ▸ | ESR1 | P03372 | 4/20 | 0.70 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.70 |
| ▸ | HSD17B1 | P14061 | 9/20 | 0.67 |
| ▸ | HSD17B2 | P37059 | 8/20 | 0.61 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.47 |
| ▸ | ESRRG | P62508 | 2/20 | 0.46 |
| ▸ | IKBKB | O14920 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14547343 | 0.89 | HSD17B1 (0.56) | APPESR1ESR2HSD17B1HSD17B2 | |
| SCHEMBL1181642 | 0.83 | APP (1.00) | APPESR1ESR2HSD17B1HSD17B2 | |
| SCHEMBL4778599 | 0.80 | APP (0.94) | APPESR1ESR2HSD17B1HSD17B2 | |
| SCHEMBL15380796 | 0.80 | APP (0.94) | APPESR1ESR2HSD17B1HSD17B2 | |
| SCHEMBL6067774 | 0.80 | HSD17B1 (0.65) | APPESR1ESR2HSD17B1HSD17B2 | |
| SCHEMBL5673936 | 0.79 | HSD17B1 (0.93) | HSD17B1HSD17B2 | |
| SCHEMBL28610244 | 0.77 | HSD17B1 (0.67) | HSD17B1HSD17B2CYP2A6IKBKB | |
| SCHEMBL13999265 | 0.77 | HSD17B1 (0.52) | APPESR1ESR2HSD17B1HSD17B2 | |
| SCHEMBL6291458 | 0.77 | HSD17B1 (0.52) | APPESR1ESR2HSD17B1HSD17B2 | |
| SCHEMBL1870857 | 0.75 | HDAC1 (0.54) | HSD17B1HSD17B2IKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090156635-A1 | BIARYLOXYMETHYLARENECARBOXYLIC ACIDS AS GLYCOGEN SYNTHASE ACTIVATORS | GILLESPIE PAUL | 2009-06-18 | — | — | US | disclosed |
| CN-101068803-A | Biaryloxymethylarene carboxylic acid compounds | HOFFMANN LA ROCHE (CH) | 2007-11-07 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090156635-A1 | BIARYLOXYMETHYLARENECARBOXYLIC ACIDS AS GLYCOGEN SYNTHASE ACTIVATORS | GYS2, GYS1, GSK3A | APP 1359/4885ESR1 1085/4885ESR2 232/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.