SCHEMBL4455618

SCHEMBL4455618

CC(C)COC(=N)Nc1nc(N)nc(N)n1

nearest known ligand 0.36

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
PRKD3 O94806 1/20 0.36
MAPK8 P45983 1/20 0.36
ALDH1A1 P00352 2/20 0.34
KDM4E B2RXH2 1/20 0.34
MAPT P10636 1/20 0.34
TSHR P16473 1/20 0.34
MAPK1 P28482 1/20 0.34
HSD17B10 Q99714 1/20 0.34
CDK1 P06493 1/20 0.34
CCNB1 P14635 1/20 0.34
CCNA2 P20248 1/20 0.34
CDK2 P24941 1/20 0.34
CCNA1 P78396 1/20 0.34
HPGD P15428 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4451761 0.76 LMNA (0.32) TSHRHSD17B10
SCHEMBL1011371 0.71 HTR7 (0.33) CDK1CCNB1CCNA2CDK2CCNA1
SCHEMBL6727050 0.69 CDK1 (0.35) CDK1CCNB1CCNA2CDK2CCNA1
SCHEMBL7132699 0.67 CDK1 (0.41) ALDH1A1CDK1CCNB1CCNA2CDK2
SCHEMBL7108420 0.67 HTR7 (0.33) CDK1CCNB1CCNA2CDK2CCNA1
SCHEMBL5157434 0.66 TSHR (0.57) ALDH1A1KDM4EMAPTTSHRMAPK1
SCHEMBL135748 0.65 LMNA (0.31)
SCHEMBL1011368 0.65 CDK1 (0.37) PRKD3MAPK8CDK1CCNB1CCNA2
SCHEMBL3298153 0.64 POLB (0.52) ALDH1A1KDM4E
SCHEMBL10942115 0.63 HTR7 (0.32) CDK1CCNB1CCNA2CDK2CCNA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 77 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108068552-B Pneumatic tire with double-layer tread 固特异轮胎和橡胶公司 2020-02-07 CN claimed
EP-3323633-B1 PNEUMATIC TIRE HAVING A DUAL LAYER TREAD GOODYEAR TIRE & RUBBER (US) 2019-10-23 EP claimed
US-10427463-B2 Pneumatic tire having a dual layer tread THE GOODYEAR TIRE & RUBBER COMPANY (US) 2019-10-01 US claimed
US-10077342-B2 Elastomeric compositions comprising cellulose ester additives EASTMAN CHEMICAL COMPANY (US) 2018-09-18 US claimed
US-10077343-B2 Process to produce elastomeric compositions comprising cellulose ester additives EASTMAN CHEMICAL COMPANY (US) 2018-09-18 US claimed
EP-3323633-A1 PNEUMATIC TIRE HAVING A DUAL LAYER TREAD The Goodyear Tire & Rubber Company (US) 2018-05-23 EP claimed
US-20180134086-A1 PNEUMATIC TIRE HAVING A DUAL LAYER TREAD GOODYEAR TIRE & RUBBER COMPANY, THE 2018-05-17 US claimed
US-20170210861-A1 PROCESS TO PRODUCE ELASTOMERIC COMPOSITIONS COMPRISING CELLULOSE ESTER ADDITIVES EASTMAN CHEMICAL COMPANY (US) 2017-07-27 US claimed
US-20170210888-A1 ELASTOMERIC COMPOSITIONS COMPRISING CELLULOSE ESTER ADDITIVES EASTMAN CHEMICAL COMPANY (US) 2017-07-27 US claimed
EP-2730431-B1 Rubber composition and tire with rubber containing flavone GOODYEAR TIRE & RUBBER (US) 2017-06-28 EP claimed
US-20120220706-A1 PNEUMATIC TIRE GOODYEAR TIRE & RUBBER COMPANY, THE 2012-08-30 US claimed
EP-2492307-A1 RUBBER COMPOSITION AND PNEUMATIC TIRE The Goodyear Tire & Rubber Company (US) 2012-08-29 EP claimed
EP-1391327-B1 Tire with rubber containing flavone GOODYEAR TIRE & RUBBER (US) 2008-09-03 EP claimed
EP-1930184-A1 Tire with apex containing in-situ resin and rubber with pendant hydroxyl groups THE GOODYEAR TIRE & RUBBER COMPANY (US) 2008-06-11 EP claimed
US-20080115874-A1 Tire with apex containing in-situ resin and rubber with pendant hydroxyl groups THIELEN GEORGES MARCEL VICTOR 2008-05-22 US claimed
US-6872771-B1 Tire with rubber containing flavone THE GOODYEAR TIRE & RUBBER COMPANY (US) 2005-03-29 US claimed
EP-1391327-A1 Tire with rubber containing flavone THE GOODYEAR TIRE & RUBBER COMPANY (US) 2004-02-25 EP claimed
US-6467520-B2 Tire with apex rubber containing in-situ resin THE GOODYEAR TIRE & RUBBER COMPANY 2002-10-22 US claimed
US-20020124927-A1 Tire with apex rubber containing in-situ resin GOODYEAR TIRE & RUBBER COMPANY, THE 2002-09-12 US claimed
EP-1216851-A1 Tire with apex rubber containing in-situ formed resin THE GOODYEAR TIRE & RUBBER COMPANY (US) 2002-06-26 EP claimed