SCHEMBL4451761

SCHEMBL4451761

COC(=N)Nc1nc(N)nc(N)n1

nearest known ligand 0.32

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.32
TP53 P04637 1/20 0.30
POLB P06746 1/20 0.30
GAA P10253 1/20 0.30
TSHR P16473 1/20 0.30
HTT P42858 1/20 0.30
HSD17B10 Q99714 1/20 0.30
NPC1 O15118 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4455618 0.76 PRKD3 (0.36) TSHRHSD17B10
SCHEMBL135748 0.75 LMNA (0.31) LMNA
SCHEMBL7776751 0.74 LMNA (0.40) LMNATP53TSHRHTTHSD17B10
SCHEMBL9739707 0.72 KMT2A (0.47) POLBGAAHTTNPC1
SCHEMBL9739607 0.71 S1PR2 (0.35)
SCHEMBL9740214 0.71 CYP1A2 (0.61) LMNATP53GAATSHRHTT
SCHEMBL3298153 0.68 POLB (0.52) LMNAPOLBGAA
SCHEMBL736035 0.68 LMNA (0.31) LMNA
SCHEMBL4630998 0.67 CA1 (0.34) LMNATP53POLBGAATSHR
Sulfuric Acid SCHEMBL128158 0.67 CA1 (0.36)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 80 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108068552-B Pneumatic tire with double-layer tread 固特异轮胎和橡胶公司 2020-02-07 CN claimed
EP-3323633-B1 PNEUMATIC TIRE HAVING A DUAL LAYER TREAD GOODYEAR TIRE & RUBBER (US) 2019-10-23 EP claimed
US-10427463-B2 Pneumatic tire having a dual layer tread THE GOODYEAR TIRE & RUBBER COMPANY (US) 2019-10-01 US claimed
US-10077342-B2 Elastomeric compositions comprising cellulose ester additives EASTMAN CHEMICAL COMPANY (US) 2018-09-18 US claimed
US-10077343-B2 Process to produce elastomeric compositions comprising cellulose ester additives EASTMAN CHEMICAL COMPANY (US) 2018-09-18 US claimed
EP-3323633-A1 PNEUMATIC TIRE HAVING A DUAL LAYER TREAD The Goodyear Tire & Rubber Company (US) 2018-05-23 EP claimed
US-20180134086-A1 PNEUMATIC TIRE HAVING A DUAL LAYER TREAD GOODYEAR TIRE & RUBBER COMPANY, THE 2018-05-17 US claimed
WO-2017127603-A1 ELASTOMERIC COMPOSITIONS COMPRISING CELLULOSE ESTER ADDITIVES EASTMAN CHEMICAL COMPANY (US) 2017-07-27 WO claimed
US-20170210888-A1 ELASTOMERIC COMPOSITIONS COMPRISING CELLULOSE ESTER ADDITIVES EASTMAN CHEMICAL COMPANY (US) 2017-07-27 US claimed
US-20170210861-A1 PROCESS TO PRODUCE ELASTOMERIC COMPOSITIONS COMPRISING CELLULOSE ESTER ADDITIVES EASTMAN CHEMICAL COMPANY (US) 2017-07-27 US claimed
EP-2492307-A1 RUBBER COMPOSITION AND PNEUMATIC TIRE The Goodyear Tire & Rubber Company (US) 2012-08-29 EP claimed
EP-1391327-B1 Tire with rubber containing flavone GOODYEAR TIRE & RUBBER (US) 2008-09-03 EP claimed
EP-1930184-A1 Tire with apex containing in-situ resin and rubber with pendant hydroxyl groups THE GOODYEAR TIRE & RUBBER COMPANY (US) 2008-06-11 EP claimed
US-20080115874-A1 Tire with apex containing in-situ resin and rubber with pendant hydroxyl groups THIELEN GEORGES MARCEL VICTOR 2008-05-22 US claimed
US-6872771-B1 Tire with rubber containing flavone THE GOODYEAR TIRE & RUBBER COMPANY (US) 2005-03-29 US claimed
EP-1391327-A1 Tire with rubber containing flavone THE GOODYEAR TIRE & RUBBER COMPANY (US) 2004-02-25 EP claimed
US-6467520-B2 Tire with apex rubber containing in-situ resin THE GOODYEAR TIRE & RUBBER COMPANY 2002-10-22 US claimed
US-20020124927-A1 Tire with apex rubber containing in-situ resin GOODYEAR TIRE & RUBBER COMPANY, THE 2002-09-12 US claimed
EP-1216851-A1 Tire with apex rubber containing in-situ formed resin THE GOODYEAR TIRE & RUBBER COMPANY (US) 2002-06-26 EP claimed
EP-0695329-B1 Method for producing laminated multilayered plastic foil structures of polyolefin using a complexable water-based paint composition containing an acrylic resin and an amino resin BASF COATINGS AG (DE) 1999-06-23 EP claimed