SCHEMBL4455945

SCHEMBL4455945

C=CCCCO[Si](C)(C)C(C)(C)C

nearest known ligand 0.37

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
DUT P33316 2/20 0.37
ALDH1A1 P00352 3/20 0.37
TSHR P16473 2/20 0.37
LPAR3 Q9UBY5 2/20 0.31
LMNA P02545 1/20 0.31
LPAR2 Q9HBW0 1/20 0.31
L3MBTL1 Q9Y468 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL592575 0.94 TSHR (0.38) DUTALDH1A1TSHRLPAR3LMNA
SCHEMBL30895945 0.92 TSHR (0.41) DUTALDH1A1TSHRLPAR3LMNA
SCHEMBL17732227 0.92 TSHR (0.41) DUTALDH1A1TSHRLPAR3LMNA
SCHEMBL1931760 0.92 TSHR (0.41) DUTALDH1A1TSHRLPAR3LMNA
SCHEMBL2245848 0.92 TSHR (0.41) DUTALDH1A1TSHRLPAR3LMNA
SCHEMBL4059577 0.86 DUT (0.33) DUTTSHR
SCHEMBL2244296 0.85 TSHR (0.36) DUTALDH1A1TSHRLPAR3LMNA
SCHEMBL27040101 0.83 DUT (0.37) DUT
SCHEMBL28538333 0.81 DUT (0.43) DUT
SCHEMBL8063404 0.81 DUT (0.43) DUT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4126855-B1 COMPOUNDS AND THEIR USE IN THE TREATMENT OF BACTERIAL INFECTIONS HOFFMANN LA ROCHE (CH) 2024-04-24 EP disclosed
US-20230357286-A1 KETONE SYNTHESIS AND APPLICATIONS PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2023-11-09 US disclosed
US-20230203058-A1 MACROCYCLIC DIAMINE DERIVATIVES AS ENT INHIBITORS FOR THE TREATMENT OF CANCERS, AND COMBINATION THEREOF WITH ADENOSINE RECEPTOR ANTAGONISTS iTeos Belgium SA (BE) 2023-06-29 US disclosed
US-20230167127-A1 COMPOUNDS AND THEIR USE IN THE TREATMENT OF BACTERIAL INFECTION HOFFMANN-LA ROCHE INC. (US) 2023-06-01 US disclosed
EP-4126855-A1 COMPOUNDS AND THEIR USE IN THE TREATMENT OF BACTERIAL INFECTION F. Hoffmann-La Roche AG (CH) 2023-02-08 EP disclosed
CN-115298176-A Compounds and their use in the treatment of bacterial infections 豪夫迈·罗氏有限公司 2022-11-04 CN disclosed
US-20220071971-A1 MACROCYCLIC COMPOUNDS AND THEIR USE IN THE TREATMENT OF DISEASE NOVARTIS AG (CH) 2022-03-10 US disclosed
US-11220513-B2 Chromium-mediated coupling and application to the synthesis of halichondrins PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2022-01-11 US disclosed
EP-3898621-A1 MACROCYCLIC COMPOUNDS AND THEIR USE IN THE TREATMENT OF DISEASE Novartis AG (CH) 2021-10-27 EP disclosed
WO-2021190727-A1 COMPOUNDS AND THEIR USE IN THE TREATMENT OF BACTERIAL INFECTION F. HOFFMANN-LA ROCHE AG (CH) 2021-09-30 WO disclosed
WO-2016176560-A1 CHROMIUM-MEDIATED COUPLING AND APPLICATION TO THE SYNTHESIS OF HALICHONDRINS PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2016-11-03 WO disclosed
US-20150309022-A1 Synthetic Ligands for the Differentiation of Closely Related Toxins and Pathogens UNIVERSITY OF CINCINNATI (US) 2015-10-29 US disclosed
US-20150231621-A1 TERMINAL ALKENE MONOISOMERIZATION CATALYSTS AND METHODS SAN DIEGO STATE UNIVERSITY RESEARCH FOUNDATION 2015-08-20 US disclosed
US-20150231621-A1 TERMINAL ALKENE MONOISOMERIZATION CATALYSTS AND METHODS SAN DIEGO STATE UNIVERSITY RESEARCH FOUNDATION 2015-08-20 US disclosed
US-20150231621-A1 TERMINAL ALKENE MONOISOMERIZATION CATALYSTS AND METHODS SAN DIEGO STATE UNIVERSITY RESEARCH FOUNDATION 2015-08-20 US disclosed
WO-2015106045-A1 PROCESSES FOR THE SYNTHESIS OF CHIRAL 1-ALKANOLS PURDUE RESEARCH FOUNDATION (US) 2015-07-16 WO disclosed
US-9045516-B2 Synthetic ligands for the differentiation of closely related toxins and pathogens UNIVERSITY OF CINCINNATI 2015-06-02 US disclosed
US-20090042816-A1 Synthetic Ligands For The Differentiation Of Closely Related Toxins And Pathogens UNIVERSITY OF CINCINNATI 2009-02-12 US disclosed
US-7169940-B1 Compounds and pharmaceutical compositions comprising same NST NEUROSURVIVAL TECHNOLOGIES LTD. (IL) 2007-01-30 US disclosed
WO-2000000514-A9 SYNTHETIC SPIROKETAL PYRANES AS POTENT ANTI-CANCER AGENTS PARKER HUGHES INST (US) 2000-07-20 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150231621-A1 TERMINAL ALKENE MONOISOMERIZATION CATALYSTS AND METHODS INF2, CPNE4, TEC DUT 2132/4885ALDH1A1 1599/4885TSHR 3666/4885
US-11220513-B2 Chromium-mediated coupling and application to the synthesis of halichondrins CROCC, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, KAT7 DUT 2428/4885ALDH1A1 999/4885TSHR 2231/4885
US-20230203058-A1 MACROCYCLIC DIAMINE DERIVATIVES AS ENT INHIBITORS FOR THE TREATMENT OF CANCERS, AND COMBINATION THEREOF WITH ADENOSINE RECEPTOR ANTAGONISTS ENTPD1, SLC29A1, ENTPD5 DUT 99/4885ALDH1A1 357/4885TSHR 778/4885
US-20220071971-A1 MACROCYCLIC COMPOUNDS AND THEIR USE IN THE TREATMENT OF DISEASE CFTR, PKD1, PKD2 DUT 3638/4885ALDH1A1 1333/4885TSHR 1576/4885
US-20230167127-A1 COMPOUNDS AND THEIR USE IN THE TREATMENT OF BACTERIAL INFECTION LTB4R, C5, C3AR1 DUT 3749/4885ALDH1A1 842/4885TSHR 1921/4885
US-20090042816-A1 Synthetic Ligands For The Differentiation Of Closely Related Toxins And Pathogens ANTXR2, VIP, C3AR1 DUT 3544/4885ALDH1A1 4038/4885TSHR 223/4885
US-20150309022-A1 Synthetic Ligands for the Differentiation of Closely Related Toxins and Pathogens ANTXR2, VIP, C3AR1 DUT 3544/4885ALDH1A1 4038/4885TSHR 223/4885
US-20230357286-A1 KETONE SYNTHESIS AND APPLICATIONS NISCH, COASY, KLK7 DUT 3686/4885ALDH1A1 1924/4885TSHR 3876/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.