Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 10/20 | 0.74 |
| ▸ | ALOX5 | P09917 | 5/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 5/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3582486 | 0.84 | ALOX5AP (1.00) | ALOX5APALOX5 | |
| SCHEMBL4319036 | 0.81 | ALOX5AP (0.65) | ALOX5APALOX5EPHX2MEN1KMT2A | |
| SCHEMBL4330604 | 0.78 | ALOX5AP (0.65) | ALOX5APALOX5EPHX2MEN1KMT2A | |
| SCHEMBL7544973 | 0.66 | NPC1 (0.77) | ALOX5APALOX5EPHX2MEN1KMT2A | |
| SCHEMBL8769691 | 0.66 | EPHX2 (0.84) | ALOX5APALOX5EPHX2MEN1KMT2A | |
| SCHEMBL8921057 | 0.65 | NPC1 (0.57) | ALOX5APALOX5EPHX2MEN1KMT2A | |
| SCHEMBL10833882 | 0.65 | ALOX5 (0.64) | ALOX5APALOX5EPHX2MEN1KMT2A | |
| SCHEMBL9422611 | 0.65 | NPC1 (0.59) | ALOX5EPHX2MEN1KMT2AALDH1A1 | |
| SCHEMBL7551599 | 0.64 | NPC1 (0.76) | ALOX5APALOX5EPHX2MEN1KMT2A | |
| SCHEMBL3572346 | 0.64 | ALOX5AP (0.72) | ALOX5APALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090197883-A1 | Diphenyl Substituted Cycloalkanes, Compositions Containing Such Compounds and Methods Of Use | MERCK SHARP & DOHME CORP. | 2009-08-06 | — | — | US | disclosed |
| US-20090197883-A1 | Diphenyl Substituted Cycloalkanes, Compositions Containing Such Compounds and Methods Of Use | MERCK SHARP & DOHME CORP. | 2009-08-06 | — | — | US | disclosed |
| US-20090197883-A1 | Diphenyl Substituted Cycloalkanes, Compositions Containing Such Compounds and Methods Of Use | MERCK SHARP & DOHME CORP. | 2009-08-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090197883-A1 | Diphenyl Substituted Cycloalkanes, Compositions Containing Such Compounds and Methods Of Use | ALOX5, LTC4S, ALOX15B | ALOX5AP 16/4885ALOX5 1/4885EPHX2 288/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.