SCHEMBL4456816

SCHEMBL4456816

O=C1c2ccccc2C(=O)N1CCCCCCS(=O)(=O)NOCCC1CCCCC1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HPGD P15428 2/20 0.47
MAPK1 P28482 2/20 0.46
ALDH1A1 P00352 2/20 0.46
HTR1A P08908 1/20 0.42
HTR7 P34969 1/20 0.42
HRH1 P35367 1/20 0.42
DRD3 P35462 1/20 0.42
HTR2B P41595 1/20 0.42
ACHE P22303 2/20 0.42
DRD2 P14416 1/20 0.39
MAPT P10636 2/20 0.39
SMN1; SMN2 Q16637 2/20 0.39
UBE2N P61088 1/20 0.39
TDP1 Q9NUW8 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
RAB9A P51151 1/20 0.39
BACE1 P56817 1/20 0.39
HDAC8 Q9BY41 3/20 0.39
HDAC3 O15379 2/20 0.39
HDAC4 P56524 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4447716 0.89 HPGD (0.49) HPGDMAPK1ALDH1A1HTR1AHTR7
SCHEMBL4457921 0.81 HPGD (0.60) HPGDMAPK1ALDH1A1HTR1AHTR7
SCHEMBL29263737 0.79 HPGD (0.59) HPGDMAPK1ALDH1A1HTR1AHTR7
SCHEMBL14450985 0.77 ACHE (0.57) HPGDMAPK1ALDH1A1HTR1AHTR7
SCHEMBL21609732 0.76 ACHE (0.59) HPGDMAPK1ALDH1A1HTR1AHTR7
SCHEMBL21609729 0.76 ACHE (0.59) HPGDMAPK1ALDH1A1HTR1AHTR7
SCHEMBL17117470 0.76 ACHE (0.59) HPGDMAPK1ALDH1A1HTR1AHTR7
SCHEMBL19739574 0.76 HPGD (0.56) HPGDMAPK1ALDH1A1HTR1AHTR7
SCHEMBL13771140 0.74 SIGMAR1 (0.49) TDP1POLB
SCHEMBL4245809 0.73 ACHE (0.71) HPGDALDH1A1HTR1AHTR7HRH1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009086835-A1 NOVEL CYANOGUANIDINES TOPOTARGET A/S (DK) 2009-07-16 WO disclosed