Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.47 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.42 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | APAF1 | O14727 | 1/20 | 0.39 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.39 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.38 |
| ▸ | CDYL2 | Q8N8U2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4457436 | 0.85 | POLB (0.39) | KDM4EHPGDHSD17B10CYP3A4CYP2D6 | |
| SCHEMBL4457005 | 0.81 | POLB (0.48) | KDM4EHSD17B10KMT2AALDH1A1MAPT | |
| SCHEMBL4453442 | 0.79 | SMN1; SMN2 (0.62) | HPGDKMT2AALDH1A1MAPT | |
| SCHEMBL3038422 | 0.79 | USP2 (0.46) | HDAC6CSNK2A2CSNK2A1PTGS2KDM4E | |
| SCHEMBL4458421 | 0.78 | SMN1; SMN2 (0.47) | KDM4EGAAKMT2AALDH1A1MAPT | |
| SCHEMBL3042764 | 0.76 | PTGS2 (0.48) | HDAC6CSNK2A2CSNK2A1PTGS2CYP3A4 | |
| SCHEMBL4462916 | 0.75 | RXFP1 (0.47) | KDM4EGAAKMT2AMAPT | |
| SCHEMBL14291770 | 0.75 | PTGS2 (0.49) | HDAC6CSNK2A2CSNK2A1PTGS2KDM4E | |
| SCHEMBL306478 | 0.74 | PTGS2 (0.46) | HDAC6CSNK2A2CSNK2A1PTGS2KDM4E | |
| SCHEMBL308328 | 0.74 | PTGS2 (0.48) | HDAC6CSNK2A2CSNK2A1PTGS2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1626964-B1 | NEW BENZIMIDAZOLE DERIVATIVES | ASTRAZENECA AB (SE) | 2009-01-21 | — | — | EP | claimed |