Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | FFAR4 | Q5NUL3 | 3/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | GRM5 | P41594 | 2/20 | 0.47 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | VCP | P55072 | 1/20 | 0.40 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8304733 | 0.88 | LMNA (0.66) | LMNATDP1FFAR4HTTGRM5 | |
| SCHEMBL1720331 | 0.81 | ALDH1A1 (0.59) | LMNATDP1FFAR4HTTGRM5 | |
| SCHEMBL2180955 | 0.81 | LMNA (0.56) | LMNATDP1HTTGRM5CYP19A1 | |
| SCHEMBL2193231 | 0.80 | LMNA (0.63) | LMNATDP1HTTGRM5CYP19A1 | |
| SCHEMBL26617005 | 0.80 | CYP3A4 (0.38) | FFAR4CYP1A2CYP2C9 | |
| SCHEMBL8804228 | 0.80 | LMNA (0.75) | LMNATDP1FFAR4HTTGRM5 | |
| SCHEMBL23391383 | 0.79 | LTA4H (0.48) | FFAR4TSHRKMT2ALTA4H | |
| SCHEMBL22061921 | 0.78 | LMNA (0.87) | LMNATDP1FFAR4HTTCYP19A1 | |
| SCHEMBL13606235 | 0.78 | FFAR4 (0.56) | LMNATDP1FFAR4HTTGRM5 | |
| SCHEMBL30564888 | 0.78 | MAOB (0.47) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090306115-A1 | Phenyl ethyne compounds | MERCK SHARP & DOHME CORP. | 2009-12-10 | — | — | US | disclosed |
| US-20090306115-A1 | Phenyl ethyne compounds | MERCK SHARP & DOHME CORP. | 2009-12-10 | — | — | US | disclosed |
| US-20090306115-A1 | Phenyl ethyne compounds | MERCK SHARP & DOHME CORP. | 2009-12-10 | — | — | US | disclosed |
| CN-101163667-A | Phenylacetylene compounds | MERCK & CO INC (US) | 2008-04-16 | — | — | CN | disclosed |
| EP-1874724-A2 | PHENYL ETHYNE COMPOUNDS | Merck & Co., Inc. (US) | 2008-01-09 | — | — | EP | disclosed |
| WO-2006115895-A2 | PHENYL ETHYNE COMPOUNDS | MERCK & CO., INC. (US) | 2006-11-02 | — | — | WO | disclosed |
| EP-1458385-A4 | HETEROARYL SUBSTITUTED IMIDAZOLE MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR-5 | MERCK & CO INC (US) | 2005-12-21 | — | — | EP | disclosed |
| US-20040259917-A1 | Heteroaryl substituted imidazole modulators of metabotropic glutamate receptor-5 | COSFORD NICHOLAS D P (US) | 2004-12-23 | — | — | US | disclosed |
| EP-1458385-A2 | HETEROARYL SUBSTITUTED IMIDAZOLE MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR-5 | Merck & Co., Inc. (US) | 2004-09-22 | — | — | EP | disclosed |
| WO-2004030637-A2 | TREATMENT OF OBESITY AND OTHER DISORDERS ASSOCIATED WITH EXCESSIVE FOOD INTAKE | MERCK & CO., INC. (US) | 2004-04-15 | — | — | WO | disclosed |
| WO-2003053922-A2 | HETEROARYL SUBSTITUTED IMIDAZOLE MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR-5 | MERCK & CO., INC. (US) | 2003-07-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090306115-A1 | Phenyl ethyne compounds | DDT, CHRM3, CBR3 | LMNA 4450/4885TDP1 3721/4885FFAR4 814/4885 |
| US-20040259917-A1 | Heteroaryl substituted imidazole modulators of metabotropic glutamate receptor-5 | GRM5, GRIK5, GRIN2C | LMNA 4706/4885TDP1 3720/4885FFAR4 965/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.