Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.75 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.75 |
| ▸ | FFAR4 | Q5NUL3 | 3/20 | 0.54 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.46 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.46 |
| ▸ | GRM5 | P41594 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.44 |
| ▸ | LTA4H | P09960 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL676142 | 0.82 | LMNA (0.82) | LMNATDP1FFAR4CYP19A1ALDH1A1 | |
| SCHEMBL7938427 | 0.82 | MAPT (0.46) | ALDH1A1SMN1; SMN2MAPTKDM4E | |
| SCHEMBL30535283 | 0.82 | LMNA (0.82) | LMNATDP1FFAR4CYP19A1ALDH1A1 | |
| SCHEMBL12635585 | 0.81 | LMNA (0.62) | LMNATDP1FFAR4CYP19A1ALDH1A1 | |
| SCHEMBL11959791 | 0.81 | LMNA (0.47) | LMNATDP1FFAR4ALDH1A1SMN1; SMN2 | |
| SCHEMBL22061921 | 0.80 | LMNA (0.87) | LMNATDP1FFAR4CYP19A1ALDH1A1 | |
| SCHEMBL4457253 | 0.80 | LMNA (0.56) | LMNATDP1FFAR4CYP19A1ALDH1A1 | |
| SCHEMBL9988598 | 0.80 | LMNA (0.56) | LMNATDP1FFAR4CYP19A1ALDH1A1 | |
| SCHEMBL1720331 | 0.80 | ALDH1A1 (0.59) | LMNATDP1FFAR4CYP19A1ALDH1A1 | |
| SCHEMBL6289878 | 0.80 | ALDH1A1 (0.50) | LMNATDP1ALDH1A1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106146518-A | A kind of bruton's tyrosine kinase inhibitor intermediate and preparation method thereof | 苏州爱玛特生物科技有限公司 | 2016-11-23 | — | — | CN | disclosed |
| CN-1694700-A | Non-nucleoside reverse transcriptase inhibitors | MEDIVIR AB (SE) | 2005-11-09 | — | — | CN | disclosed |
| EP-0556813-B1 | Amphoteric tricyclic compounds as antihistaminic and antiallergic agents | HOKURIKU PHARMACEUTICAL (JP) | 1997-11-26 | — | — | EP | disclosed |
| US-5334594-A | Antihistamines, antiallergens | HOKORIKU PHARMACEUTICAL CO., LTD. (JP) | 1994-08-02 | — | — | US | disclosed |
| EP-0556813-A1 | Amphoteric tricyclic compounds as antihistaminic and antiallergic agents | HOKURIKU PHARMACEUTICAL CO., LTD. (JP) | 1993-08-25 | — | — | EP | disclosed |
| US-4229457-A | TREATMENT OF SENILITY | WARNER-LAMBERT COMPANY (US) | 1980-10-21 | — | — | US | disclosed |