Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 10/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4650239 | 1.00 | ACE (0.49) | ACEL3MBTL1LMNAKMT2APOLB | |
| SCHEMBL300279 | 1.00 | ACE (0.49) | ACEL3MBTL1LMNAKMT2APOLB | |
| SCHEMBL300278 | 1.00 | ACE (0.49) | ACEL3MBTL1LMNAKMT2APOLB | |
| SCHEMBL4400451 | 1.00 | ACE (0.49) | ACEL3MBTL1LMNAKMT2APOLB | |
| SCHEMBL13482629 | 1.00 | ACE (0.49) | ACEL3MBTL1LMNAKMT2APOLB | |
| SCHEMBL4458267 | 1.00 | ACE (0.49) | ACEL3MBTL1LMNAKMT2APOLB | |
| SCHEMBL1992431 | 1.00 | ACE (0.49) | ACEL3MBTL1LMNAKMT2APOLB | |
| SCHEMBL4400447 | 1.00 | ACE (0.49) | ACEL3MBTL1LMNAKMT2APOLB | |
| Hydrochloric Acid SCHEMBL5287673 | 0.98 | ACE (0.48) | ACEL3MBTL1LMNAKMT2APOLB | |
| Hydrochloric Acid SCHEMBL3536442 | 0.98 | ACE (0.48) | ACEL3MBTL1LMNAKMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4183450-A1 | METHOD FOR PREPARING A HYDRATED FORM OF PERINDOPRIL L-ARGININE | Zupet, Rok (SI) | 2023-05-24 | — | — | EP | disclosed |
| CN-103193863-B | The preparation method of the L arginine salt of perindopril | 瑟维尔实验室 | 2017-03-01 | — | — | CN | disclosed |
| CN-101553463-B | Pharmaceutical intermediates in the synthesis of ACE-inhibitors and uses thereof | EGIS GYOGYSZERGYAR NYILVANOSAN MUKODO RESZVENYTARSASAG | 2013-12-04 | — | — | CN | disclosed |
| US-7521566-B2 | Process for preparation of perindopril and salts thereof | LES LABORATOIRES SERVIER (FR) | 2009-04-21 | — | — | US | disclosed |
| US-7521566-B2 | Process for preparation of perindopril and salts thereof | LES LABORATOIRES SERVIER (FR) | 2009-04-21 | — | — | US | disclosed |
| US-7521566-B2 | Process for preparation of perindopril and salts thereof | LES LABORATOIRES SERVIER (FR) | 2009-04-21 | — | — | US | disclosed |
| US-7456296-B2 | Method for preparation of crystalline perindopril erbumine | LUPIN LTD (IN) | 2008-11-25 | — | — | US | disclosed |
| US-7456296-B2 | Method for preparation of crystalline perindopril erbumine | LUPIN LTD (IN) | 2008-11-25 | — | — | US | disclosed |
| EP-1603558-B1 | PROCESS FOR PREPARATION OF PERINDOPRIL AND SALTS THEREOF | SERVIER S A LAB (FR) | 2008-05-21 | — | — | EP | disclosed |
| US-20070149604-A1 | Reacting perindopril in a solvent selected from N,N-dimethylformamide, dimethoxymethane, 2,2-dimethoxypropane and 1,2-dimethoxyethane with tert-butylamine, crystallization; stereospecific | LUPIN LTD. (IN) | 2007-06-28 | — | — | US | disclosed |
| US-20070149604-A1 | Reacting perindopril in a solvent selected from N,N-dimethylformamide, dimethoxymethane, 2,2-dimethoxypropane and 1,2-dimethoxyethane with tert-butylamine, crystallization; stereospecific | LUPIN LTD. (IN) | 2007-06-28 | — | — | US | disclosed |
| US-20060276659-A1 | Process for preparation of perindopril and salts thereof | LIPIN LIMITED (IN) | 2006-12-07 | — | — | US | disclosed |
| EP-1603558-A1 | PROCESS FOR PREPARATION OF PERINDOPRIL AND SALTS THEREOF | Lupin Limited (IN) | 2005-12-14 | — | — | EP | disclosed |
| WO-2004075889-A1 | PROCESS FOR PREPARATION OF PERINDOPRIL AND SALTS THEREOF | LUPIN LIMITED (IN) | 2004-09-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060276659-A1 | Process for preparation of perindopril and salts thereof | CYP2C9, DPYD, CYP2C8 | ACE 10/4885L3MBTL1 2978/4885LMNA 806/4885 |
| US-20070149604-A1 | Reacting perindopril in a solvent selected from N,N-dimethylformamide, dimethoxymethane, 2,2-dimethoxypropane and 1,2-dimethoxyethane with tert-butylamine, crystallization; stereospecific | REN, AGTR2, AGTR1 | ACE 8/4885L3MBTL1 3821/4885LMNA 1430/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.