Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 20/20 | 0.67 |
| ▸ | PPARG | P37231 | 9/20 | 0.67 |
| ▸ | PPARD | Q03181 | 7/20 | 0.58 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.54 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.54 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.54 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.54 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.54 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3946807 | 0.80 | PPARA (1.00) | PPARAPPARGPPARDPSEN1PSEN2 | |
| SCHEMBL4459430 | 0.80 | PPARA (0.69) | PPARAPPARGPPARD | |
| SCHEMBL4450745 | 0.79 | PPARA (0.51) | PPARAPPARGPPARDPSEN1PSEN2 | |
| SCHEMBL28622516 | 0.77 | ALOX15 (0.60) | PPARAPPARGPPARD | |
| SCHEMBL10834946 | 0.76 | PPARA (0.55) | PPARAPPARGPPARDPSEN1PSEN2 | |
| SCHEMBL4450866 | 0.76 | PPARA (0.58) | PPARAPPARGPPARDPSEN1PSEN2 | |
| SCHEMBL10599678 | 0.75 | GAA (0.67) | — | |
| SCHEMBL8078006 | 0.75 | GAA (0.67) | — | |
| SCHEMBL10600889 | 0.75 | GAA (0.67) | — | |
| SCHEMBL4458645 | 0.75 | CYP3A4 (0.50) | PPARAPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7482484-B2 | Carboxylic acids and derivatives for the treatment of and preventing diabetes and dyslipidaemia | MERCK PATENT GMBH (DE) | 2009-01-27 | — | — | US | disclosed |