Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 4/20 | 0.31 |
| ▸ | APP | P05067 | 2/20 | 0.31 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.30 |
| ▸ | JAK2 | O60674 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4459721 | 0.88 | PDPK1 (0.30) | PDPK1JAK2 | |
| SCHEMBL4458379 | 0.71 | CYP3A4 (0.35) | — | |
| SCHEMBL1172224 | 0.68 | BACE1 (0.32) | BACE1 | |
| SCHEMBL1172351 | 0.66 | BACE1 (0.38) | BACE1APP | |
| SCHEMBL1172247 | 0.65 | ALDH1A1 (0.41) | — | |
| SCHEMBL4462368 | 0.65 | HTR5A (0.32) | — | |
| SCHEMBL1171761 | 0.64 | APP (0.32) | BACE1APP | |
| SCHEMBL1171746 | 0.64 | CTSD (0.32) | BACE1 | |
| SCHEMBL1171733 | 0.62 | KDM1A (0.39) | BACE1APP | |
| SCHEMBL1172133 | 0.62 | BACE1 (0.39) | BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009017838-A2 | COMBINATIONS OF JAK-2 INHIBITORS AND OTHER AGENTS | EXELIXIS, INC. (US) | 2009-02-05 | — | — | WO | claimed |