Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | PRPS1 | P60891 | 1/20 | 0.37 |
| ▸ | HCAR1 | Q9BXC0 | 2/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.32 |
| ▸ | GRM2 | Q14416 | 3/20 | 0.32 |
| ▸ | ESR1 | P03372 | 2/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.31 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31698451 | 0.72 | ESR1 (0.41) | POLBPRPS1HCAR1ARESR1 | |
| SCHEMBL27625206 | 0.69 | AR (0.40) | POLBPRPS1HCAR1ARESR1 | |
| SCHEMBL25922298 | 0.69 | PRPS1 (0.41) | POLBPRPS1HCAR1ARKCNH2 | |
| SCHEMBL3037828 | 0.67 | AR (0.47) | POLBPRPS1ARLMNACYP3A4 | |
| SCHEMBL30317200 | 0.65 | JAK1 (0.47) | PRPS1EPHX2CYP1A2MAPK1CYP2C19 | |
| SCHEMBL31415669 | 0.63 | AR (0.43) | POLBPRPS1ARKCNH2GRM2 | |
| SCHEMBL24346878 | 0.62 | POLB (0.39) | POLBPRPS1HCAR1CYP1A2FGFR1 | |
| SCHEMBL937961 | 0.60 | HCAR1 (0.34) | POLBPRPS1HCAR1AREPHX2 | |
| SCHEMBL19678220 | 0.60 | POLB (0.50) | POLBHCAR1KCNH2ALDH1A1 | |
| SCHEMBL7811170 | 0.60 | HSD11B1 (0.38) | PRPS1KCNH2GRM2ESR1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2042490-A2 | Benzimidazole derivatives as vanilloid receptor antagonists | AstraZeneca AB (SE) | 2009-04-01 | — | — | EP | disclosed |