Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRPS1 | P60891 | 1/20 | 0.41 |
| ▸ | AR | P10275 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | ESR1 | P03372 | 2/20 | 0.36 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.34 |
| ▸ | HCAR1 | Q9BXC0 | 2/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.32 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31698451 | 0.86 | ESR1 (0.41) | PRPS1ARPOLBESR1CDK1 | |
| SCHEMBL25922278 | 0.77 | HCAR1 (0.34) | HCAR1 | |
| SCHEMBL25923933 | 0.75 | HCAR3 (0.38) | PRPS1ESR1HSD11B1P2RX7KCNH2 | |
| SCHEMBL3037931 | 0.70 | PRPS1 (0.54) | PRPS1ARPOLBESR1HCAR1 | |
| SCHEMBL27625206 | 0.70 | AR (0.40) | PRPS1ARPOLBESR1HCAR1 | |
| SCHEMBL30317078 | 0.69 | PRPS1 (0.41) | PRPS1ARHTR1A | |
| SCHEMBL4459295 | 0.69 | POLB (0.38) | PRPS1ARPOLBESR1HCAR1 | |
| SCHEMBL25924821 | 0.69 | ESR1 (0.35) | POLBESR1HSD11B1P2RX7 | |
| SCHEMBL3037828 | 0.68 | AR (0.47) | PRPS1ARPOLB | |
| SCHEMBL31415669 | 0.64 | AR (0.43) | PRPS1ARPOLBP2RX7KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023141432-A2 | APOL1 INHIBITORS AND METHODS OF USE | MAZE THERAPEUTICS, INC. (US) | 2023-07-27 | — | — | WO | disclosed |