SCHEMBL4459302

SCHEMBL4459302

CSc1cc(CO)ccc1O

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX15 P16050 7/20 0.42
MAPT P10636 5/20 0.42
KMT2A Q03164 5/20 0.42
HSD17B10 Q99714 5/20 0.42
GAA P10253 4/20 0.42
HPGD P15428 4/20 0.42
ALOX12 P18054 4/20 0.42
MEN1 O00255 3/20 0.42
TP53 P04637 3/20 0.42
LMNA P02545 2/20 0.42
TRPA1 O75762 2/20 0.39
KDM4E B2RXH2 6/20 0.39
ALDH1A1 P00352 6/20 0.39
POLB P06746 2/20 0.39
TTR P02766 2/20 0.38
ESR1 P03372 3/20 0.38
ALOX5 P09917 2/20 0.38
ESR2 Q92731 1/20 0.38
BACE1 P56817 1/20 0.38
BAD Q92934 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2090992 0.83 ALDH1A1 (0.38) MAPTHSD17B10TRPA1ALDH1A1TTR
SCHEMBL24038795 0.82 ALOX15 (0.41) ALOX15MAPTKMT2AHSD17B10GAA
SCHEMBL23278455 0.79 MAPT (0.39) ALOX15MAPTKMT2AHSD17B10GAA
SCHEMBL8787271 0.79 XDH (0.40) ALOX15MAPTKMT2AHSD17B10GAA
SCHEMBL20349306 0.78 ALDH1A1 (0.33) MAPTHSD17B10ALDH1A1TTRTSHR
SCHEMBL28554718 0.78 SLC6A2 (0.37) MAPTHSD17B10ALDH1A1TTRTSHR
SCHEMBL20179614 0.77 PTPN1 (0.56) ALOX15CYP3A4CNR1IGF1RPTGS2
SCHEMBL2090095 0.76 EGFR (0.38) MAPTHSD17B10LMNATRPA1ALDH1A1
SCHEMBL841432 0.75 ALDH1A1 (0.40) MAPTHSD17B10HPGDALDH1A1ESR1
SCHEMBL5757525 0.73 SLC6A2 (0.40) ALOX15MAPTHSD17B10ALDH1A1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7582660-B2 2-thio-substituted imidazole derivatives and their use in pharmaceutics C-A-I-R BIOSCIENCES GMBH (DE) 2009-09-01 US disclosed
EP-1539741-A1 2-THIO-SUBSTITUTED IMIDAZOLE DERIVATIVES AND THEIR USE IN PHARMACEUTICS MERCKLE GMBH (DE) 2005-06-15 EP disclosed
WO-2004018458-A1 2-THIO-SUBSTITUTED IMIDAZOLE DERIVATIVES AND THEIR USE IN PHARMACEUTICS MERCKLE-GMBH (DE) 2004-03-04 WO disclosed
EP-1112265-B1 2-ARYLALKYLTHIO -IMIDAZOLES, 2-ARYLALKENYL -THIO -IMIDAZOLES AND 2-ARYLALKINYL -THIO -IMIDAZOLES AS ANTI -INFLAMMATORY SUBSTANCES AND SUBSTANCES INHIBITING THE RELEASE OF CYTOKINE MERCKLE GMBH (DE) 2004-01-14 EP disclosed
EP-1112265-A1 2-ARYLALKYLTHIO -IMIDAZOLES, 2-ARYLALKENYL -THIO -IMIDAZOLES AND 2-ARYLALKINYL -THIO -IMIDAZOLES AS ANTI -INFLAMMATORY SUBSTANCES AND SUBSTANCES INHIBITING THE RELEASE OF CYTOKINE MERCKLE GMBH (DE) 2001-07-04 EP disclosed
WO-2000017192-A1 2-ARYLALKYLTHIO -IMIDAZOLES, 2-ARYLALKENYL -THIO -IMIDAZOLES AND 2-ARYLALKINYL -THIO -IMIDAZOLES AS ANTI -INFLAMMATORY SUBSTANCES AND SUBSTANCES INHIBITING THE RELEASE OF CYTOKINE MERCKLE GMBH (DE) 2000-03-30 WO disclosed