Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 4/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 5/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 4/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | ERN1 | O75460 | 1/20 | 0.35 |
| ▸ | TUBB4A | P04350 | 5/20 | 0.33 |
| ▸ | TUBB | P07437 | 5/20 | 0.33 |
| ▸ | TUBA3C | P0DPH7 | 5/20 | 0.33 |
| ▸ | TUBA1B | P68363 | 5/20 | 0.33 |
| ▸ | TUBA4A | P68366 | 5/20 | 0.33 |
| ▸ | TUBB4B | P68371 | 5/20 | 0.33 |
| ▸ | TUBB3 | Q13509 | 5/20 | 0.33 |
| ▸ | TUBB2A | Q13885 | 5/20 | 0.33 |
| ▸ | TUBB8 | Q3ZCM7 | 5/20 | 0.33 |
| ▸ | TUBA3E | Q6PEY2 | 5/20 | 0.33 |
| ▸ | TUBA1A | Q71U36 | 5/20 | 0.33 |
| ▸ | TUBA1C | Q9BQE3 | 5/20 | 0.33 |
| ▸ | TUBB6 | Q9BUF5 | 5/20 | 0.33 |
| ▸ | TUBB2B | Q9BVA1 | 5/20 | 0.33 |
| ▸ | TUBB1 | Q9H4B7 | 5/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4465487 | 0.75 | CYP2A6 (0.39) | CYP2A6PDGFRBPDGFRAPRMT6CYP2E1 | |
| SCHEMBL4463698 | 0.71 | CYP2A6 (0.36) | CYP2A6PDGFRBPDGFRAERN1PRMT6 | |
| SCHEMBL5991209 | 0.68 | CYP2A6 (0.46) | CYP2A6PDGFRBPDGFRANPC1ERN1 | |
| SCHEMBL4853131 | 0.67 | ABL1 (0.36) | CYP2A6NPC1CYP2E1CYP2B6 | |
| SCHEMBL4473652 | 0.67 | CYP1A1 (0.35) | PDGFRBERN1TUBB4ATUBBTUBA3C | |
| SCHEMBL29234155 | 0.65 | ERN1 (0.58) | CYP2A6PDGFRBPDGFRANPC1ERN1 | |
| SCHEMBL1069430 | 0.63 | ALDH1A1 (0.43) | CYP2A6PDGFRBPDGFRANPC1CYP2E1 | |
| SCHEMBL336435 | 0.63 | PDE4B (0.38) | CYP2A6NPC1CYP2E1CYP2B6 | |
| SCHEMBL26414634 | 0.62 | ERN1 (0.50) | CYP2A6PDGFRBPDGFRAERN1TUBB4A | |
| SCHEMBL5992568 | 0.62 | GAK (0.48) | CYP2A6PDGFRBPDGFRANPC1ERN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7521454-B2 | Adenine derivatives | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2009-04-21 | — | — | US | disclosed |
| EP-1386923-B1 | NOVEL ADENINE DERIVATIVES | DAINIPPON SUMITOMO PHARMA CO (JP) | 2008-08-13 | — | — | EP | disclosed |
| US-20070037832-A1 | 2-butylamino-8-hydroxy-9-(6-methyl-3-pyridylmethyl)adenine; interferon inducing activity; antiviral, antiallergic agent; immune response modulator; hepatitis B and C, asthma, atopic dermatitis | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2007-02-15 | — | — | US | disclosed |
| US-7157465-B2 | Adenine derivatives | DAINIPPON SIMITOMO PHARMA CO., LTD. (JP) | 2007-01-02 | — | — | US | disclosed |
| US-20040132748-A1 | Novel adenne derivatives | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2004-07-08 | — | — | US | disclosed |
| EP-1386923-A1 | NOVEL ADENINE DERIVATIVES | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2004-02-04 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040132748-A1 | Novel adenne derivatives | IRF3, IFNAR1, STING1 | CYP2A6 3427/4885PDGFRB 4295/4885PDGFRA 4442/4885 |
| US-20070037832-A1 | 2-butylamino-8-hydroxy-9-(6-methyl-3-pyridylmethyl)adenine; interferon inducing activity; antiviral, antiallergic agent; immune response modulator; hepatitis B and C, asthma, atopic dermatitis | IRF3, IFNAR1, IFNG | CYP2A6 432/4885PDGFRB 2678/4885PDGFRA 3743/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.