Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 5/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.46 |
| ▸ | KCNN4 | O15554 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 7/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | KIF11 | P52732 | 1/20 | 0.35 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6337202 | 0.86 | KCNN4 (0.59) | CYP19A1CYP3A4CYP3A5KCNN4TSHR | |
| SCHEMBL11860326 | 0.83 | HSD11B1 (0.47) | CYP19A1KCNN4TSHRTDP1ALDH1A1 | |
| SCHEMBL11871226 | 0.83 | KCNN4 (0.42) | CYP19A1CYP3A4CYP3A5KCNN4TSHR | |
| SCHEMBL4470543 | 0.83 | KCNN4 (0.42) | CYP19A1CYP3A4CYP3A5KCNN4TSHR | |
| SCHEMBL4469654 | 0.83 | CYP19A1 (0.53) | CYP19A1CYP3A4CYP3A5KCNN4TSHR | |
| SCHEMBL4475144 | 0.81 | TSHR (0.50) | CYP19A1CYP3A4KCNN4TSHRMAPK1 | |
| SCHEMBL11355578 | 0.80 | CYP19A1 (0.44) | CYP19A1CYP3A4CYP3A5KCNN4TSHR | |
| SCHEMBL30869981 | 0.79 | TSHR (0.65) | CYP19A1CYP3A4CYP3A5KCNN4TSHR | |
| SCHEMBL11864594 | 0.79 | NFE2L2 (0.39) | CYP19A1CYP3A4CYP3A5KCNN4TSHR | |
| SCHEMBL11865116 | 0.79 | TSHR (0.39) | CYP19A1CYP3A4CYP3A5TSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7576088-B2 | Benzodioxole derivatives | HOFFMAN-LA ROCHE INC. (US) | 2009-08-18 | — | — | US | disclosed |
| CN-100486973-C | Novel benzodioxoles | HOFFMANN LA ROCHE (CH) | 2009-05-13 | — | — | CN | disclosed |
| EP-1532132-B1 | NOVEL BENZODIOXOLES | HOFFMANN LA ROCHE (CH) | 2008-03-19 | — | — | EP | disclosed |
| CN-1671684-A | New benzodioxoles | HOFFMANN LA ROCHE (CH) | 2005-09-21 | — | — | CN | disclosed |
| US-20050143373-A1 | Benzodioxole derivatives | ALANINE ALEXANDER (FR) | 2005-06-30 | — | — | US | disclosed |
| US-6900227-B2 | Benzodioxole derivatives | HOFFMANN-LA ROCHE INC. (US) | 2005-05-31 | — | — | US | disclosed |
| EP-1532132-A1 | NOVEL BENZODIOXOLES | F.HOFFMANN-LA ROCHE AG (CH) | 2005-05-25 | — | — | EP | disclosed |
| US-20040142922-A1 | Benzodioxole derivatives | HOFFMANN-LA ROCHE INC. | 2004-07-22 | — | — | US | disclosed |
| WO-2004013120-A1 | NOVEL BENZODIOXOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2004-02-12 | — | — | WO | disclosed |
| WO-2002042246-A1 | METHOD FOR THE PREPARATION OF DICHLORODIARYLMETHANES | TESSENDERLO CHEMIE N.V. (BE) | 2002-05-30 | — | — | WO | disclosed |
| US-3985766-A | ANTIMYCOTICS | BAYER AKTIENGESELLSCHAFT (DT) | 1976-10-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050143373-A1 | Benzodioxole derivatives | CNR2, CNR1, GPR119 | CYP19A1 51/4885CYP3A4 313/4885CYP3A5 130/4885 |
| US-20040142922-A1 | Benzodioxole derivatives | CNR1, CNR2, GPR119 | CYP19A1 32/4885CYP3A4 273/4885CYP3A5 160/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.