Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 16/20 | 0.68 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.68 |
| ▸ | TSHR | P16473 | 1/20 | 0.63 |
| ▸ | HPGD | P15428 | 1/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.55 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.55 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.55 |
| ▸ | HTR2A | P28223 | 1/20 | 0.55 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29902243 | 0.92 | MPO (0.76) | MPOSLC6A4TSHRHPGDCYP2C19 | |
| SCHEMBL3655654 | 0.92 | MPO (0.76) | MPOSLC6A4TSHRHPGDCYP2C19 | |
| SCHEMBL5203631 | 0.89 | MPO (0.80) | MPOSLC6A4TSHRNOTUMMTNR1A | |
| SCHEMBL4352009 | 0.89 | MPO (0.74) | MPOSLC6A4HTR2ATRPM8 | |
| SCHEMBL5344966 | 0.88 | MPO (0.80) | MPOSLC6A4TSHRNOTUMMTNR1A | |
| SCHEMBL5338627 | 0.87 | MPO (0.78) | MPOSLC6A4TSHRNOTUMMTNR1A | |
| SCHEMBL5203031 | 0.85 | MPO (0.73) | MPOSLC6A4HTR2ATRPM8 | |
| SCHEMBL3702252 | 0.83 | MPO (0.67) | MPOSLC6A4NOTUMMTNR1AMTNR1B | |
| SCHEMBL3695233 | 0.81 | MPO (1.00) | MPOSLC6A4TSHRNOTUMMTNR1A | |
| SCHEMBL5637957 | 0.81 | HTR2A (0.63) | MPOSLC6A4TSHRHPGDCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009137733-A1 | INDOLYLALKYL DERIVATIVES OF PYRIMIDINYLPIPERAZINE AND METABOLITES THEREOF FOR TREATMENT OF ANXIETY, DEPRESSION, AND SEXUAL DYSFUNCTION | FABRE-KRAMER PHARMACEUTICALS, INC. (US) | 2009-11-12 | — | — | WO | disclosed |