Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 15/20 | 0.80 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.73 |
| ▸ | TSHR | P16473 | 1/20 | 0.68 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.59 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.59 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.59 |
| ▸ | HTR2A | P28223 | 1/20 | 0.58 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.58 |
| ▸ | HTR1A | P08908 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5338627 | 0.99 | MPO (0.78) | MPOSLC6A4TSHRNOTUMMTNR1A | |
| SCHEMBL5203631 | 0.96 | MPO (0.80) | MPOSLC6A4TSHRNOTUMMTNR1A | |
| SCHEMBL29902243 | 0.90 | MPO (0.76) | MPOSLC6A4TSHRNOTUMMTNR1A | |
| SCHEMBL3655654 | 0.90 | MPO (0.76) | MPOSLC6A4TSHRNOTUMMTNR1A | |
| SCHEMBL2410329 | 0.89 | MPO (1.00) | MPOSLC6A4TSHRNOTUMMTNR1A | |
| SCHEMBL4463073 | 0.88 | MPO (0.68) | MPOSLC6A4TSHRNOTUMMTNR1A | |
| SCHEMBL3695233 | 0.84 | MPO (1.00) | MPOSLC6A4TSHRNOTUMMTNR1A | |
| SCHEMBL19051589 | 0.84 | MPO (0.68) | MPOSLC6A4TSHRNOTUMMTNR1A | |
| Oxalic Acid SCHEMBL3699113 | 0.84 | MPO (0.84) | MPOSLC6A4TSHRNOTUMHTR2A | |
| SCHEMBL5792523 | 0.83 | MPO (0.78) | MPOSLC6A4TSHRNOTUMMTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7173045-B2 | 4-aminomethyl-1-aryl-cyclohexylamine compounds | GRUENENTHAL GMBH (DE) | 2007-02-06 | — | — | US | claimed |
| US-20050245593-A1 | 4-Aminomethyl-1-aryl-cyclohexylamine compounds | GRUENENTHAL GMBH (DE) | 2005-11-03 | — | — | US | claimed |
| US-7173045-B2 | 4-aminomethyl-1-aryl-cyclohexylamine compounds | GRUENENTHAL GMBH (DE) | 2007-02-06 | — | — | US | disclosed |
| US-20050245593-A1 | 4-Aminomethyl-1-aryl-cyclohexylamine compounds | GRUENENTHAL GMBH (DE) | 2005-11-03 | — | — | US | disclosed |
| EP-1562891-A1 | 4-AMINOMETHYL-1-ARYL-CYCLOHEXYLAMINE DERIVATIVES | Grünenthal GmbH (DE) | 2005-08-17 | — | — | EP | disclosed |
| WO-2004043899-A1 | 4-AMINOMETHYL-1-ARYL-CYCLOHEXYLAMINE DERIVATIVES | Grünenthal GmbH (DE) | 2004-05-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050245593-A1 | 4-Aminomethyl-1-aryl-cyclohexylamine compounds | HNMT, PNMT, INMT | MPO 2831/4885SLC6A4 49/4885TSHR 1669/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.