SCHEMBL4464378

SCHEMBL4464378

O=Cc1ccc(Br)cc1Oc1ccccc1

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.62
GAA P10253 1/20 0.62
KMT2A Q03164 1/20 0.62
ALDH1A1 P00352 4/20 0.47
CYP1A2 P05177 1/20 0.47
CYP2C9 P11712 1/20 0.47
CYP2C19 P33261 1/20 0.47
SLC6A4 P31645 1/20 0.47
HTR6 P50406 1/20 0.47
NPSR1 Q6W5P4 1/20 0.46
TTR P02766 1/20 0.44
PTGDR2 Q9Y5Y4 2/20 0.43
ERN1 O75460 3/20 0.42
TSHR P16473 2/20 0.41
HTT P42858 2/20 0.39
HPGD P15428 2/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
TLR4 O00206 1/20 0.37
TLR2 O60603 1/20 0.37
LTA4H P09960 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2075254 0.86 LMNA (0.62) LMNAGAAKMT2AALDH1A1CYP1A2
SCHEMBL12953423 0.84 MAOB (0.49) LMNAGAAKMT2ACYP1A2CYP2C19
SCHEMBL13160900 0.83 LMNA (0.42) LMNAGAAKMT2AALDH1A1CYP1A2
SCHEMBL1849155 0.82 LMNA (0.67) LMNAGAAKMT2AALDH1A1CYP1A2
SCHEMBL3950719 0.82 LMNA (0.46) LMNAGAAKMT2AALDH1A1CYP1A2
SCHEMBL12953293 0.80 NPSR1 (0.64) LMNAGAAKMT2AALDH1A1CYP1A2
SCHEMBL13581108 0.80 MAOA (0.41) LMNAGAAKMT2AALDH1A1CYP1A2
SCHEMBL13580771 0.80 ALDH1A1 (0.42) LMNAGAAKMT2AALDH1A1CYP1A2
SCHEMBL12952741 0.79 CYP2C9 (0.40) LMNAGAAKMT2AALDH1A1CYP1A2
SCHEMBL20536242 0.79 LMNA (0.62) LMNAGAAKMT2AALDH1A1CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 63 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119192126-A Preparation method of oxygen/thioxanthone compound 湖南科技大学 2024-12-27 CN disclosed
US-12018004-B2 Carbamate compounds and methods of making and using same H. LUNDBECK A/S (DK) 2024-06-25 US disclosed
US-20230312499-A1 CARBAMATE COMPOUNDS AND METHODS OF MAKING AND USING SAME H. LUNDBECK A/S (DK) 2023-10-05 US disclosed
US-20230312499-A1 CARBAMATE COMPOUNDS AND METHODS OF MAKING AND USING SAME H. LUNDBECK A/S (DK) 2023-10-05 US disclosed
US-20230312499-A1 CARBAMATE COMPOUNDS AND METHODS OF MAKING AND USING SAME H. LUNDBECK A/S (DK) 2023-10-05 US disclosed
US-11530189-B2 Carbamate compounds and methods of making and using same H. LUNDBECKA/S (DK) 2022-12-20 US disclosed
US-11530189-B2 Carbamate compounds and methods of making and using same H. LUNDBECKA/S (DK) 2022-12-20 US disclosed
CN-107982266-B Carbamate compounds and methods of making and using the same H.隆德贝克有限公司 2021-07-30 CN disclosed
US-20210188793-A1 CARBAMATE COMPOUNDS AND METHODS OF MAKING AND USING SAME LUNDBECK LA JOLLA RESEARCH CENTER, INC. 2021-06-24 US disclosed
US-20210188793-A1 CARBAMATE COMPOUNDS AND METHODS OF MAKING AND USING SAME LUNDBECK LA JOLLA RESEARCH CENTER, INC. 2021-06-24 US disclosed
US-7629366-B2 Aminoalcohol derivatives FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2009-12-08 US disclosed
WO-2009125606-A1 PAI-1 INHIBITOR 株式会社医薬分子設計研究所 (JP) 2009-10-15 WO disclosed
US-20060100252-A1 Aminoalcohol derivatives FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2006-05-11 US disclosed
US-7037938-B2 Aminoalcohol derivatives ASTELLAS PHARMA INC. (JP) 2006-05-02 US disclosed
EP-1546086-A2 AMINOALCOHOL DERIVATIVES FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2005-06-29 EP disclosed
US-6713474-B2 SERINE-THREONINE AND TYROSINE KINASE INHIBITORS ABBOTT GMBH & CO. KG (DE) 2004-03-30 US disclosed
US-20040006143-A1 For therapy of urinary incontinence FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2004-01-08 US disclosed
WO-2004002939-A2 AMINOALCOHOL DERIVATIVES FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2004-01-08 WO disclosed
US-20030153752-A1 Pyrrolopyrimidines as therapeutic agents ABBVIE DEUTSCHLAND GMBH & CO KG (DE) 2003-08-14 US disclosed
WO-2001072751-A1 PYRROLOPYRIMIDINES AS TYROSINE KINASE INHIBITORS KNOLL GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) 2001-10-04 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11530189-B2 Carbamate compounds and methods of making and using same ABHD6, ABHD16A, RABL6 LMNA 4184/4885GAA 742/4885KMT2A 1102/4885
US-20030153752-A1 Pyrrolopyrimidines as therapeutic agents FLT1, FLT4, TFPI LMNA 4657/4885GAA 4375/4885KMT2A 2637/4885
US-20210188793-A1 CARBAMATE COMPOUNDS AND METHODS OF MAKING AND USING SAME ABHD6, ABHD16A, RABL6 LMNA 4184/4885GAA 742/4885KMT2A 1102/4885
US-20060100252-A1 Aminoalcohol derivatives H1-0, CHRM2, CHRM1 LMNA 3590/4885GAA 3421/4885KMT2A 1218/4885
US-20230312499-A1 CARBAMATE COMPOUNDS AND METHODS OF MAKING AND USING SAME ABHD6, ABHD16A, RABL6 LMNA 4184/4885GAA 742/4885KMT2A 1102/4885
US-20040006143-A1 For therapy of urinary incontinence H1-0, HRH2, H1-2 LMNA 4565/4885GAA 3352/4885KMT2A 364/4885
US-12018004-B2 Carbamate compounds and methods of making and using same ABHD6, ABHD16A, RABL6 LMNA 4184/4885GAA 742/4885KMT2A 1102/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.